| 王盟,贾松柏.兔眼玻切及C3F8填充术后房水bFGF含量与白内障形成的实验研究[J].济宁医学院学报,2014,(2):81-83 |
| 兔眼玻切及C3F8填充术后房水bFGF含量与白内障形成的实验研究 |
| The correlationship between the content of bFGF in the aqueous humor and the development of PCO(posterior capsular opacity) following the joint operation of vitrectomy and C3F8 tamponade on rabbit's eye |
| 投稿时间：2014-03-12 |
| DOI：10.3969/j.issn.1000-9760.2014.02.002 |
| 中文关键词: 玻璃体切除术;C3F8;白内障;bFGF |
| 英文关键词: Vitrectomy;C3F8;PCO;bFGF |
| 基金项目: |
| 作者 | 单位 | E-mail | | 王盟 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011
中南大学湘雅二医院, 湖南长沙 410011 | | | 贾松柏 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011
中南大学湘雅二医院, 湖南长沙 410011 | jsb88cn@126.com |
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| 中文摘要: |
| 目的 研究玻璃体切除联合全氟丙烷(C3F8)填充术后形成白内障的兔房水碱性成纤维细胞生长因子(bFGF)含量变化与白内障形成之间的关系。方法 18只成年纯系新西兰白兔(雌雄不限)的36只眼,随机平均分为3组:正常组,不做手术;对照组,行单纯玻璃体切除术及眼前房灌注液(BSS)填充;实验组,行玻璃体切除联合C3F8填充术。术后第1,3,8,35及45天观察各组白内障的形成情况,并抽取房水用ELISA法检测房水中bFGF的含量。结果 正常组与对照组均未出现晶体混浊,实验组均出现晶体混浊。术后不同时期,实验组与对照组的bFGF含量均明显高于正常组。术后第1,3,8天,实验组的bFGF含量明显高于对照组,有显著性差异 (P<0.05)。结论 C3F8填充引起房水中bFGF的升高与引发一过性白内障的形成有关。 |
| 英文摘要: |
| Objective To investigate the possible correlationship between the content of bFGF in the aqueous humor and the development of PCO(posterior capsular opacity)following the joint operation of vitrectomy and C3F8 tamponade.Methods 18 adult and pure-breed New Zealand white rabbits were selected,and all their 36 eyes as subjects of the experiment were taken.They were assigned into three groups randomly,i.e.12 eyes per group.Blank control group would receive none operation.Control group which would undergo the vitrectomy.Experimental group which would accept the joint operation of vitrectomy and C3F8 tamponade.Afterwards,the development of PCO was observed and the bFGF content was measured in subject's aqueous humor on the next 1,3,8,35,45 days respectively.Results All subjects in blank control group and control group hadn't shown PCO during the experiment.All subjects in experimental group had shown PCO.The bFGF in control group and experimental group were significantly higher than blank control group.Experimental group was also higer than Control group throughtout the experimental period.Conclusion C3F8 tamponade will raise the content of bFGF in the aqueous humor which may potentially contribute to the development of PCO. |
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