| 孔霞,贾少辉,葛东明.非离子表面活性剂囊泡对钙黄绿素包封作用的研究[J].济宁医学院学报,2011,(5):308-311 |
| 非离子表面活性剂囊泡对钙黄绿素包封作用的研究 |
| The study of the encapsulation function of calcein by the nonionic surfactant noiosomes |
| 投稿时间：2011-09-15 |
| DOI：10.3969/j.issn.1000-9760.2010.05.002 |
| 中文关键词: 非离子表面活性剂紫可见分光光度法;钙黄绿素;囊泡;包封率 |
| 英文关键词: Calcein;Vesicles;Entrapment efficiency;Non-ionic surfactant |
| 基金项目:2009年济宁市科技局立项项目 |
| 作者 | 单位 | | 孔霞 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 贾少辉 | 济宁医学院分子医学与化学实验室, 山东济宁 272067 | | 葛东明 | 枣庄市食品药品监督管理局台儿庄区分局, 山东枣庄 277100 |
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| 中文摘要: |
| 目的 研究非离子表面活性剂囊泡对钙黄绿素包封率的影响,为新型药物传输系统的研究提供一定的依据。方法 以司盘60和胆固醇为主要原料,通过薄膜分散法制备了非离子表面活性剂囊泡,研究了该类囊泡对钙黄绿素的包封作用以及影响包封率的因素,并利用正交实验设计优化了其最佳包封条件。结果 表面活性剂浓度、水化时间、水化温度、胆固醇用量、胆固醇与表面活性剂比例均对包封率有明显的影响。最佳包封条件为:胆固醇的摩尔质量0.2mol、水化时间45min、水化温度65℃、司盘60摩尔质量为0.3mol。结论 非离子表面活性剂囊泡对钙黄绿素具有较强的包封能力,钙黄绿素可作为研究该类囊泡作为药物载体的模型药物。 |
| 英文摘要: |
| Objective To investigate the encapsulation function of calcein by the nonionic surfactant noiosomes, and provide the guidance for the study of the new drug delivery system.Methods Niosomes were prepared with nonion surfactant span60 and cholesterol by Film dispersion method.The entrapment efficiency of calcein and the influence factors on the entrapment efficiency were studied, moreover the orthogonal test was used to study the optimal encapsulation conditions.Results The results showed that the entrapment efficiency of calcein was influenced obviously by the follows:concentration of the surfactant, the hydration time, the hydration temperature and the amount of cholesterol, and the optimal encapsulation conditions were:cholesterol 0.2mol, hydration time 45min, hydration temperature 65℃, Span 60 0.3mol.Conclusion The encapsulation function of the calcein by the nonionic surfactant noiosomes was strong, and the calcein could be used as model drug for this kind of noiosomes. |
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