| 孟纯阳.诱导多能干细胞治疗脊髓损伤的现状与展望[J].济宁医学院学报,2013,(3):153-156 |
| 诱导多能干细胞治疗脊髓损伤的现状与展望 |
| Present state and perspectives of treatment of spinal cord injury with induced pluripotent stem cells |
| 投稿时间：2013-05-15 |
| DOI： |
| 中文关键词: 脊髓损伤;诱导多能干细胞;细胞治疗 |
| 英文关键词: Spinal cord injury;Induced pluripotent stem cell;Cell therapy |
| 基金项目:山东省高等学校科技计划资助项目(编号 J11LF19) |
| 作者 | 单位 | | 孟纯阳 | 济宁医学院附属医院, 山东济宁 272029 |
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| 中文摘要: |
| 脊髓损伤主要是由外伤、脊髓疾病以及医源性损伤等因素引发,往往导致脊髓局部缺血受损从而引起相应支配区域肢体的感觉和运动功能丧失。脊髓损伤的修复和治疗一直是世界研究的热点和难点。尽管目前医疗技术和手术方法较前显著提高,但现有的治疗脊髓损伤的方法和疗效依然与临床需求相差甚远。由于脊髓损伤常可导致病人不同程度的神经功能受损而出现全瘫或不全瘫痪,给个人、家庭和国家带来了巨大经济和社会负担,因此亟需开发出新疗法以提高脊髓损伤的治疗效果。近年来干细胞研究的迅猛发展使得干细胞应用于脊髓损伤治疗成为可能,干细胞治疗作为脊髓损伤的一个重要有前途的领域也已被提出并付诸实践,最近一些干细胞治疗的临床试验不仅启动,也在不同国度进行了报道,并引起了全球广泛关注。本文总结了脊髓损伤治疗的现状,介绍诱导多能干细胞的来源以及生物学特性,探讨诱导多能干细胞的分化潜能以及诱导多能干细胞应用于脊髓损伤治疗的展望。 |
| 英文摘要: |
| Spinal cord injury is mainly due to various injuries such as trauma, ischemia, and iatrogenic injury, which usually leads to loss of sensory and motor function of the limbs of patients. Although medical technology and surgical methods have improved, the treatment of spinal cord injury is still limited. Since it could result in varying degrees of permanent loss of neurological function and disability of patients and it is a great burden for both families and the society, it is necessary to find a new strategy to treat spinal cord injury. The rapid development of research on stem cells makes it possible to treat spinal cord injury with stem cells. Recent clinical trials of stem cell therapy for spinal cord injury have been reported and attracted wide attention in the whole world. In this article, the development of the treatment of spinal cord injury has been summarized; the sources and biological characteristics of induced pluripotent stem cells have been introduced; the outlook of differentiation potential of pluripotent stem cells and its application for treatment of spinal cord injury have been made. |
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