| 张波,王慧云,全先高.非离子表面活性剂囊泡作为头孢匹胺钠药物载体的研究[J].济宁医学院学报,2011,(4):236-239,242 |
| 非离子表面活性剂囊泡作为头孢匹胺钠药物载体的研究 |
| Studies on niosomes as drug carrier of Cefpiramide Sodium for Injection |
| 投稿时间：2011-07-03 |
| DOI：10.3969/j.issn.1000-9760.2011.04.003 |
| 中文关键词: 非离子表面活性剂囊泡;头孢匹胺钠;包封率 |
| 英文关键词: Nonionic surfactant vesicles;Cefpiramide Sodium for Injection;encapsulation efficiency |
| 基金项目: |
| 作者 | 单位 | | 张波 | 济宁医学院基础医学与法医学院, 山东济宁 272067 | | 王慧云 | 济宁医学院药学院, 山东日照 276826 | | 全先高 | 济宁医学院药学院, 山东日照 276826 |
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| 中文摘要: |
| 目的 研究非离子表面活性剂囊泡对头孢匹胺钠的包封率及其释放行为的影响,为新型药物传输系统的研究提供一定的依据。方法 以司盘60和胆固醇为主要原料,通过薄膜分散法制备了非离子表面活性剂囊泡,研究了该类囊泡对头孢匹胺钠的包封作用,包封率的影响因素以及被包封的头孢匹胺钠在模拟胃液及模拟肠液中的释放情况。结果 0.10 mol/L 司盘60:胆固醇=4:3时形成的非离子表面活性剂囊泡对1.0 mg/ml的头孢匹胺钠的包封率是88%;药物释放实验显示,在模拟胃液和模拟肠液中游离的头孢匹胺钠释放率为96%,包封于囊泡中的头孢匹胺钠的释放率为25%。结论 非离子表面活性剂囊泡对头孢匹胺钠具有较高的包封率及明显缓释作用。 |
| 英文摘要: |
| Objective To investigate the entrapment efficiency and the release rate of Cefpiramide Sodium for Injection capsulated into noiosomes,and provide the guidance for the study of the new drug delivery system.Methods Niosomes were prepared with nonion surfactant span60 and cholesterol by ultasonication.And we measured the entrapment efficiency of Cefpiramide Sodium for Injection encapsulated into noiosomes and release profiles in simulated gastric and intestinal fluid.Results The results showed that the entrapment efficiency of Cefpiramide Sodium for Injection by noiosomes reached 88 % under the condition that the molar ratio of the span 40:cholesterol equaled to 4:3 and the concentration of Cefpiramide Sodium for Injection was 1.0mg/ml.In simulated gastric and intestinal fluid the release rate of Cefpiramide Sodium for Injection entrapped in niosomes was 25 % after 6h,however the release rate of free Cefpiramide Sodium for Injection was 96% under the same condition.Conclusion The entrapment efficiency of Cefpiramide Sodium for Injection entrapped by niosomes was high enough and the release rate of the entrapped drug was slow obviously. |
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