|
| 外周血中性粒细胞与淋巴细胞比值对动脉瘤性蛛网膜下腔出血疗效的预测价值 |
| Predictive value of peripheral blood neutrophil-to-lymphocyte ratio in the treatment of aneurysmal subarachnoid hemorrhage |
| 投稿时间：2021-12-01 修订日期：2022-01-20 |
| DOI： |
| 中文关键词: 动脉瘤性蛛网膜下腔出血;中性粒细胞与淋巴细胞比值;生物学标记;预后 |
| 英文关键词: aneurysmal subarachnoid hemorrhage; neutrophil-to-lymphocyte ratio; biomarkers; outcome |
| 基金项目:国家自然科学(81771360)；济宁市重点研发计划(软科学项目)(2020JNZC039)；济宁市重点研发计划项目（2020JKNS012） |
| 作者 | 单位 | 邮编 | | 张丽丽 | 济宁医学院附属医院 | 272029 | | 胡铭 | 济宁医学院附属医院 | | | 邹慧敏 | 济宁医学院附属医院 | | | 冯勋刚 | 济宁医学院附属医院 | | | 郝延磊* | 济宁医学院附属医院 | 272029 |
|
| 摘要点击次数: 477 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 探讨外周血中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio, NLR)对动脉瘤性蛛网膜下腔出血（aneurysmal subarachnoid hemorrhage, aSAH）疗效的预测价值。方法 这项观察性研究包括了所有连续5年(2015年1月至2019年12月)在济宁医学院附属医院神经内科和神经外科住院的aSAH患者413例。根据患者发病3个月后改良Rankin量表(modified Rankin Scale, mRS)，分为预后良好组(mRS评分 0-2)和预后不良组(mRS评分3-6)。通过单因素及多变量分析，调查与不良预后独立相关的因素。结果 两组患者性别比例、年龄、高血压病、糖尿病、冠心病史、吸烟史、饮酒、红细胞计数、血红蛋白、血小板、血钾、血糖、血尿素氮、血肌酐，差异均无统计学意义(P＞0.05)；两组之间患者入住ICU、Hunt-Hess分级、改良Fisher分级、白细胞计数、淋巴细胞百分比、单核细胞百分比、中性粒细胞百分比、淋巴细胞计数、中性粒细胞计数、外周血NLR、血钠、活化部分凝血活酶时间、肺炎、谷丙转氨酶，差异均有统计学意义(P＜0.05)。多因素Logistic回归分析，结果显示，Hunt-Hess分级、入住ICU、NLR是aSAH预后不良的独立危险因素。结论 外周血NLR对aSAH患者预后不良有一定预测价值，可以作为aSAH预后不良的独立危险因素。 |
| 英文摘要: |
| Objective The authors sought to investigate the predictive value of peripheral blood neutrophil-to-lymphocyte ratio (NLR) in the treatment of aneurysmal subarachnoid hemorrhage (aSAH). Methods This retrospective study included all consecutive 413 aSAH patients admitted to subsidiary hospital of Jining Medical University over a 5-year period (2015–2019). Data regarding patient demographics and clinical, laboratory, and in-hospital measures, as well as neuroradiological data, were retrieved from institutional databases. Functional outcome was assessed at 3 months using the modified Rankin Scale (mRS) score and categorized into favorable (mRS score 0–2) and unfavorable (mRS score 3–6). Clinical data was compared between the two groups，influencing factors of mRS in patients with aSAH were analyzed by multivariate Logistic regression analysis，and ROC curve was drawn to evaluate the predictive value of peripheral blood NLR on functional outcome in patients with aSAH.
Results No statistically significant differences of male, age, between attack and admission, incidence of hypertension or diabetes, coronary heart disease, smoking rate, drinking rate, RBC, Hb, PLT, serum potassium, blood glucose, blood urea nitrogen or serum creatinine was found between the two groups (P ＞0.05) ; proportion of patients with 3 to 6 in ICU, Hunt-Hess grading, modified Fisher grading, incidence of WBC, LYMPH%, NOMO%, NEUT%, LYMPH, NEUT, peripheral blood NLR, serum sodium, APTT, pulmonary condition, ALT and blood glucose of tow groups were statistically significantly Pulmonary condition (P＜0. 05). Multivariate Logistic regression analysis showed that Hunt-Hess grading, ICU admission and NLR were independent risk factors for poor prognosis of aSAH.
Conclusion Peripheral blood NLR in one of risk factors of unfavorable functional outcome in patients with aSAH, peripheral blood NLR has certain predictive value on unfavorable functional outcome in patients with aSAH． |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
|
|
|
