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| 血浆PMP和EMP对急性缺血性脑卒中患者颈动脉狭窄的影响研究 |
| Influence study between circulating platelets microparticles and endothelial microparticls and carotid artery stenosis in patients with acute ischemic stroke |
| 投稿时间：2020-07-12 修订日期：2020-09-09 |
| DOI： |
| 中文关键词: 颈动脉狭窄;血小板微粒体;内皮细胞微粒体 |
| 英文关键词: carotid artery stenosis; Platelets microparticles; Endothelial microparticles |
| 基金项目: |
| 作者 | 单位 | 邮编 | | 付晓玲 | 德州市人民医院超声医学科 | 253014 | | 杜茜 | 山东第一医科大学第一附属医院（山东省千佛山医院） | | | 王军 | 山东省中医药大学附属医院东区放射科 | | | 曲立新* | 德州市人民医院神经内科 | 253014 |
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| 中文摘要: |
| 目的 探讨血浆血小板微粒体(PMP)和内皮细胞微粒体(EMP)水平与急性缺血性脑卒中(AIS)患者颈动脉狭窄(CAS)的关系。方法 以德州市人民医院神经内科2018年9月至2019年12月收治的178例AIS患者为研究对象。以狭窄率≥50%为脉狭窄组和狭窄率＜50%为对照组。分析PMP和EMP含量与CAS的相关性。结果 狭窄组93人,对照组85人。狭窄组的血浆PMP和EMP水平显著高于对照组 (P＜0.05)。且控制其他影响因素后,发现PMP和EMP水平是影响CAS患者的独立预测因子。结论 血浆PMP和EMP水平可能作为临床上评估CAS发生的指标。 |
| 英文摘要: |
| Objective To explore the relationship between circulating platelets microparticles (PMP) and endothelial microparticls (EMP) and carotid artery stenosis (CAS) in patients with acute ischemic stroke (AIS). Methods 178 Patients with AIS hospitalized from September, 2018 to December, 2019 in Dezhou People’s Hospital were selected. The stenosis rate ≥50% was used as the pulse stenosis group and the stenosis rate < 50% was used as the control group.The correlation between PMP and EMP contents and CAS was analyzed. Results There were 93 patients in the stenosis group and 85 in the control group. The level of plasma PMP and EMP in the stenosis group were significantly higher than those in the control group (P < 0.05). After controlling for other influencing factors, PMP and EMP levels were found to be independent predictors affecting patients with CAS. Conclusion Circulating PMP and EMP levels are associated with CAS, which play important roles in the progress of CAS patients. |
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