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| 卡拉胶-琼脂和羟丙基-β-环糊精复合凝胶的合成及载药性能研究 |
| Synthesis of the hydrogel formed by carrageenan-Agar and hydroxypropyl-β-cyclodextrin and its controlled drug release |
| 投稿时间：2020-02-20 修订日期：2020-05-11 |
| DOI： |
| 中文关键词: 卡拉胶；琼脂；羟丙基-β-环糊精；复合凝胶；体外释放；甲氨蝶呤 |
| 英文关键词: Carrageenan; Agar; Hydroxypropyl-β-cyclodextrin; Composite hydrogel; In vitro drug release; Methotrexate |
| 基金项目:济宁医学院青年教师科研扶持基金 卡拉胶、刺槐豆胶和羟丙基-β-环糊精复配凝胶的合成及载药性能研究 |
| 作者 | 单位 | 邮编 | | 张波 | 济宁医学院 | 272067 | | 苏衍华 | 济宁医学院药学院2015级学生 | | | 庞丽艳 | 济宁医学院药学院2015级学生 | | | 王继燕 | 济宁医学院 | | | 李兆楼 | 济宁医学院 | 272067 | | 王凤琴* | 济宁医学院 | |
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| 中文摘要: |
| 摘 要 目的：利用卡拉胶、琼脂和羟丙基-β-环糊精合成了新型的复合凝胶，研究了该凝胶的外观形貌、微观结构、物理化学性质及载药性能。方法：采用溶胶-凝胶法合成该复合凝胶，使用光学显微镜（OM）、扫描电子显微镜（SEM）、红外光谱（IR）、X射线衍射（XRD）、流变学方法等物理手段研究凝胶样品的结构、性质、性能等；通过对载药凝胶包封率、体外释放试验等考察复合凝胶对药物的缓控释作用。结果： 制备了新型的卡拉胶-琼脂和羟丙基-β-环糊精复合凝胶及其载药凝胶，试验表明该凝胶性质稳定，载药凝胶包封率为50.29%；载药凝胶体外药物释放试验还表明，凝胶体系加入羟丙基-β-环糊精，能使甲氨蝶呤载药凝胶的释药率降低接近10%。结论；新型的复合凝胶合成方法简便、成本较低，且对药物具有较高的包封率及明显缓控释作用。 |
| 英文摘要: |
| Abstract: Objective A hydrogel formed by hydroxypropyl-β-cyclodextrin, carrageenan and Agar was synthesized, and its microstructure, morphology, physical properties and drug-carrying properties were further explored. Methods The sol-gel method was used to obtain the composite hydrogel, and the structure and properties of the gel sample were studied by optical microscope, scanning electron microscope, infrared spectroscopy, X-ray diffraction, differential thermal scanner and rheology. The sustained and controlled release effect of the composite hydrogel system on drug was verified by encapsulation rate and in vitro drug release assay. Results This composite hydrogel and its drug-carrying hydrogel were successfully obtained. The composite hydrogel can be stored for a long time. The encapsulation rate of drug methotrexate in the composite hydrogel was up to 50.29%. In vitro drug release assay showed that addition of hydroxypropyl-β-cyclodextrin into the carrageenan-agar hydrogel could reduce the release rate of methotrexate by about 10%. Conclusion The composite hydrogel obtained showed high encapsulation rate and significant delay and control effect on drug methotrexate release. |
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