| 李甜宁,王辉.生物相容性胶体颗粒稳定的Pickering乳液体系对姜黄素药效的影响[J].济宁医学院学报,2023,46(3):200-205 |
| 生物相容性胶体颗粒稳定的Pickering乳液体系对姜黄素药效的影响 |
| Effect of Pickering emulsions stablized by biocompatible colloidal partides on the physicochemical properties and pharmacological curcumin |
| 投稿时间：2022-08-29 |
| DOI：10.3969/j.issn.1000-9760.2023.03.011 |
| 中文关键词: 生物大分子;软胶体颗粒;姜黄素;Pickering乳液;药效作用 |
| 英文关键词: Biological macromolecules;Soft colloidal particle;Curcumin;Pickering emulsion;Pharmacological effects |
| 基金项目:国家自然科学基金面上项目(81973767) |
|
| 摘要点击次数: 754 |
| 全文下载次数: 439 |
| 中文摘要: |
| 合理的剂型是改善难溶性药物生物利用度的有效途径,姜黄素具有多种药理活性,但生物利用度较低。由生物大分子自组装的软胶体颗粒稳定的Pickering乳液体系,因其良好的结构可控性、生物相容性被广泛应用于生物医药载体材料,利用该体系作为姜黄素载体,可明显提高姜黄素的靶向作用,改善其药效作用。本文归纳了生物相容性胶体颗粒稳定的姜黄素Pickering乳液药效活性研究进展,阐明了“界面膜结构-姜黄素乳液的理化性质-药效”的关系,并展望了其未来发展方向及潜在的应用途径。 |
| 英文摘要: |
| The curcumin was demonstrated possessing many pharmacological effects while its bioavailability is low.Appropriate pharmaceutical formulations of curcumin are effective methods to improve its pharmacological.Pickering emulsion dispersion system stabilized by particles have been widely utilized in biomedical carriers.Pickering emulsions stabilized by "soft colloidal particles" that self-assembled by biological macromolecules showed better structural controllability and biocompatibility.The Pickering emulsion encapsulating the curcumin has exhibited the significant advantages in maintaining structural controllability,high-efficient targeting and fulfilling specific pharmacodynamic functions.In this paper,we summarized the research progress of pharmacological effects and bioactivity of curcumin Pickering emulsions stabilized by the biocompatible particles.The relationship of "the interface films structures-properties of curcumin Pickering emulsions-pharmacological effects" were expressed in detail.The future development direction and potential application approaches of curcumin Pickering emulsions were prospected. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
