| 张昊萌,李长忠.接触蛋白1与恶性肿瘤[J].济宁医学院学报,2022,45(4):283-288 |
| 接触蛋白1与恶性肿瘤 |
| CNTN-1 protein and malignant tumors |
| 投稿时间：2022-01-05 |
| DOI：10.3969/j.issn.1000-9760.2022.04.013 |
| 中文关键词: 接触蛋白1;恶性肿瘤;血管内皮生长因子-C;上皮细胞-间充质转化 |
| 英文关键词: Contactin 1;Vascular endothelial growth factor-C;Epithelial-mesenchymal transition |
| 基金项目: |
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| 摘要点击次数: 978 |
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| 中文摘要: |
| 接触蛋白1(contactin 1,CNTN-1)是免疫球蛋白超家族成员之一,属于糖基酰肌醇锚定的神经细胞黏附因子。CNTN-1在胃癌、肺癌、甲状腺癌、食管鳞癌、宫颈癌等恶性肿瘤中表达增加,且与上述癌症患者肿瘤细胞发展、浸润和转移密切相关。目前,CNTN-1蛋白在恶性肿瘤疾病发展中的作用及其作用机制研究甚少。本文对近年关于CNTN-1蛋白在癌症中表达、作用与作用机制、预后的相关研究进展做一综述。 |
| 英文摘要: |
| Contactin 1 (CNTN-1) is a member of the immunoglobulin superfamily and belongs to the nerve cell adhesion molecule anchored by glycosyl phosphatidylimosita.More and more reports indicate that CNTN-1 is up-regulated in gastric cancer,lung cancer,thyroid cancer,esophageal squamous cell carcinoma,cervical cancer and other malignant tumors,and is closely related to the disease development,invasion and metastasis of the above-mentioned tumor patients.However,there are few studies on the role of CNTN-1 protein in the occurrence,development,metastasis,and invasion of malignant tumors and its related mechanisms.The following is a summary of the recent progress in research on the role of CNTN-1 protein in cancer and its related mechanisms. |
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