| 王凯,刘福朋,赵倩倩,晏文华,张梅.2型糖尿病患者血压水平与糖尿病肾病发生风险的关联性[J].济宁医学院学报,2022,45(2):85-88 |
| 2型糖尿病患者血压水平与糖尿病肾病发生风险的关联性 |
| Correlation between blood pressure and risk of diabetic nephropathy in patients with type 2 diabetes |
| 投稿时间：2021-03-09 |
| DOI：10.3969/j.issn.1000-9760.2022.02.003 |
| 中文关键词: 2型糖尿病;糖尿病肾病;血压 |
| 英文关键词: Type 2 diabetes;Diabetic nephropathy;Blood pressure |
| 基金项目: |
| 作者 | 单位 | 邮编 | | 王凯 | 济宁医学院临床医学院 | 272013 | | 刘福朋 | 济宁医学院附属医院 | 272029 | | 赵倩倩 | 济宁医学院附属医院 | 272029 | | 晏文华 | 济宁医学院附属医院 | 272029 | | 张梅* | 济宁医学院附属医院 | 272029 |
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| 中文摘要: |
| 目的 探讨2型糖尿病患者血压水平与糖尿病肾病发生风险的关联性，分析糖尿病肾病发病风险升高时的血压阈值。 方法 纳入2017年7月1日至2021年4月30在济宁医学院附属医院内分泌遗传代谢科住院并行糖尿病肾病筛查的2型糖尿病患者，采用logistic单因素回归分析，平滑曲线拟合分析血压水平与糖尿病肾病的关联性，通过计算优势比，确定血压增加时发生糖尿病肾病发生风险。 结果 共纳入2型糖尿病患者2415例，平均年龄(54.77±12.08)岁，平均病程(8.74±6.92)年。其中男性、糖尿病病程、体重、BMI、腰围、收缩压、舒张压、甘油三酯与糖尿病肾病风险呈正相关联。2型糖尿病患者收缩压、舒张压与糖尿病肾病的发生呈U型关系，当收缩压＞158mmHg时，收缩压每增加1mmHg，糖尿病肾病发生风险增加4%，差异具有统计学意义(P < 0.05)；舒张压＞70mmHg时，舒张压每增加1mmHg，糖尿病肾病发生风险增加1%，差异具有统计学意义(P < 0.05)。 结论 当2型糖尿病患者收缩压＞158mmHg或舒张压＞70mmHg时，其发生糖尿病肾病的风险显著增加。 |
| 英文摘要: |
| Objective To explore the correlation between blood pressure and the risk of diabetic nephropathy in patients with type 2 diabetes and to identify the threshold of blood pressure for patients when they have a high risk of diabetic nephropathy. Methods Patients with type 2 diabetes hospitalized in the Affiliated Hospital of Jining Medical University and screened for diabetic nephropathy from Jul 1, 2017 to Apr 30, 2021 were included in this research.The correlation between variables was analyzed by single-factor analysis.The relationship between blood pressure and the risk of diabetic nephropathy was analyzed by smoothing curve fitting.Moreover, the odds ratio was calculated to determine the risk of diabetic nephropathy with the increase of blood pressure. Results A total of 2415 patients with type 2 diabetes were enrolled, with an average age of (54.77±12.08) years and an average disease duration of (8.74±6.92) years.Male, duration of diabetes, body weight, BMI, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglyceride are positively correlated with the risk of diabetic nephropathy.There are U-shape relationships between SBP and DBP with diabetic nephropathy.When the SBP is above 158mmHg, 1mmHg increase of SBP leads to 4% increase of risk of diabetic nephropathy.When the DBP is above 70mmHg, 1mmHg increase of DBP leads to 1% increase of risk of diabetic nephropathy. Conclusion The patients with type 2 diabetes have high risks of diabetic nephropathy with systolic blood pressure >158mmHg or diastolic blood pressure >70mmHg. |
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