| 杨韦,余逗逗,段维维,唐小伟.缺陷型精神分裂症患者认知功能与社会功能的相关性[J].济宁医学院学报,2021,44(5):319-322,326 |
| 缺陷型精神分裂症患者认知功能与社会功能的相关性 |
| The correlation of cognitive function and social function in patients with deficient schizophrenia |
| 投稿时间：2021-03-25 |
| DOI：10.3969/j.issn.1000-9760.2021.05.004 |
| 中文关键词: 缺陷型精神分裂症;认知功能;社会功能 |
| 英文关键词: Deficit schizophrenia;Cognitive function;Social function |
| 基金项目:江苏省卫计委青年医学人才项目（QNRC2016314）；扬州市“十三五”科教强卫专项经费（ZDRC201842）；扬州市社会发展项目（YZ2020104）；江苏省卫生健康委科研面上项目（M2020031） |
| 作者 | 单位 | E-mail | | 杨韦 | 山东省戴庄医院, 济宁 272051 | | | 余逗逗 | 扬州五台山医院, 扬州 225003 | | | 段维维 | 济宁医学院精神卫生学院, 济宁 272013 | | | 唐小伟 | 扬州五台山医院, 扬州 225003
扬州大学医学院附属五台山医院, 扬州 225003 | shrimp200@aliyun.com |
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| 中文摘要: |
| 目的 探讨缺陷型精神分裂症（deficit schizophrenia，DS）与非缺陷型精神分裂症（non-deficit schizophrenia，NDS）患者认知功能、社会功能状况及其关联性，以进一步了解社会功能的影响因素。方法 纳入年龄、教育程度相匹配的DS患者53例和NDS患者57例，采用阳性与阴性症状量表（positive and negative symptom scale，PANSS）、Mattis痴呆评定量表-2（Mattis dementia rating scale，MDRS-2）、简易精神状态检查（mini-mental state examination，MMSE）和社会适应量表（social-adaptive functioning evaluation，SAFE）分别评估患者的临床症状、认知功能与社会功能。结果 与NDS组相比，DS组MDRS-2各因子分、总分和MMSE得分均较低（P<0.05），SAFE得分、PANSS阴性症状分、一般精神病理分、总分均较高（P<0.05）。相关分析显示，DS组SAFE得分与年龄（r=0.38，P<0.05）、病程（r=0.52，P<0.05）与阴性症状分（r=0.35，P<0.05）呈正相关；与MDRS-2注意因子分（r=-0.53，P<0.05）、起始/保存因子分（r=-0.58，P<0.05）、概念形成因子分（r=-0.55，P<0.05）、结构因子分（r=-0.65，P<0.05）、记忆记忆因子分（r=-0.51，P<0.05）、总分（r=-0.64，P<0.05）和MMSE得分（r=-0.55，P<0.05）均呈负相关。NDS组SAFE得分与年龄（r=0.50，P<0.05）、病程（r=0.41，P<0.05）、阳性症状分（r=0.38，P<0.05）、阴性症状分（r=0.42，P<0.05）和总分（r=0.41，P<0.05）呈正相关；与MDRS-2各因子、总分和MMSE得分均无相关性。分别对两组社会功能的影响因素进行回归分析显示，DS组SAFE得分与MDRS-2总分负相关（β=-0.61，P<0.05）；与病程（β=0.37，P<0.05）呈正相关。NDS组SAFE得分与阳性症状分（β=0.39，P<0.05）、年龄（β=0.38，P<0.05）呈正相关。结论 DS患者社会功能和认知功能显著差于NDS患者。认知障碍可能是影响DS患者社会功能恢复的重要因素。 |
| 英文摘要: |
| Objective To explore the cognitive function and social function of patients with deficit schizophrenia(DS) and non-deficit schizophrenia(NDS) and their correlation, so as to further understand the influencing factors of social function.Methods 53 DS patients and 57 NDS patients with matching age and education level were enrolled.Positive and negative symptom scale(PANSS), Mattis dementia rating scale-2(MDRS-2), mini-mental state examination(MMSE) and social-adaptive functioning scale(SAFE) were used to evaluate the clinical symptoms, cognitive function and social function of the patients, respectively.Results Compared with NDS group, all factors scores and total scores of MDRS-2 and the scores of MMSE in DS group were lower(P<0.05), while the scores of SAFE, negative symptom score, general psychopathology score and total score of PANSS were higher(P<0.05).Correlation analysis showed that the SAFE score of DS group was positively correlated with age(r=0.38, P<0.05), course of disease(r=0.52, P<0.05) and negative symptom score(r=0.35, P<0.05), and was negatively correlated with MDRS-2 attention factor score(r=-0.53, P<0.05), start/save factor score(r=-0.58, P<0.05), concept formation factor score(r=-0.55, P<0.05), structure factor score(r=-0.65, P<0.05), memory factor score(r=-0.51, P<0.05), total score(r=-0.64, P<0.05), and MMSE score(r=-0.55, P<0.05).In NDS group, the score of SAFE was positively correlated with age(r=0.50, P<0.05), course of disease(r=0.41, P<0.05), positive symptom score(r=0.38, P<0.05), negative symptom score(r=0.42, P<0.05) and total score(r=0.41, P<0.05), and was not correlated with all factors, total score of MDRS-2 and MMSE score.Conclusion This study found that the social function and cognitive function of DS patients were significantly worse than those of NDS patients.Cognitive impairment may be an important factor for the recovery of social function in patients with DS. |
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