文章摘要
李超,吴磊,张艳淑.紫茎泽兰羟基泽兰酮在大鼠体内毒代动力学与组织分布[J].济宁医学院学报,2021,44(4):238-241
紫茎泽兰羟基泽兰酮在大鼠体内毒代动力学与组织分布
Toxicokinetics and tissue distribution of Euptox A in rats
投稿时间:2021-06-18  
DOI:10.3969/j.issn.1000-9760.2021.04.003
中文关键词: 紫茎泽兰羟基泽兰酮;毒代动力学;组织分布
英文关键词: Euptox A;Toxicokinetics;Tissue distribution
基金项目:国家公益性行业科研专项(201103027)
作者单位E-mail
李超 华北理工大学公共卫生学院, 唐山 063210
山东省职业卫生与职业病防治研究院, 济南 250062 
 
吴磊 华北理工大学公共卫生学院, 唐山 063210  
张艳淑 华北理工大学公共卫生学院, 唐山 063210 yanshuzhang@ncst.edu.cn 
摘要点击次数: 127
全文下载次数: 0
中文摘要:
      目的 探讨紫茎泽兰羟基泽兰酮(Euptox A)在大鼠体内的毒代动力学和组织分布。方法 将15只Wistar大鼠随机分为3组,每组5只;分别静脉给予Euptox A 25、50和100mg·kg-1后,于不同时间点采集血样;另18只大鼠随机分为3组,每组6只;静脉给予Euptox A 50mg·kg-1后,分别于10、60和120min后采集心、肝、脾、肺、肾、脑、胃、肠、睾丸、肌肉和血样,采用高效液相色谱法测定血浆和组织中Euptox A的含量。运用DAS 2.0药代动力学智能分析软件计算毒代动力学参数。结果 大鼠静脉给予Euptox A 25、50和100mg·kg-1后,体内毒代动力学符合线性毒代动力学特点,半衰期分别为(27.4±6.7)、(21.6±5.4)、(18.3±5.8) min;最大血药浓度分别为(2.57±0.60)、(5.83±0.94)、(10.72±2.08) mg·L-1;AUC分别为(2039.4±835.3)、(4277.2±1194.6)、(7842.7±1077.8) mg·min-1·L-1。大鼠静脉给予Euptox A 50mg·kg-1后10min,各组织含量达到最高,60min后明显下降,在体内各组织分布广泛,其中血液、肝脏和心脏中分布较高。结论 大鼠静脉给予Euptox A后代谢符合线性毒代动力学特点,在大鼠体内分布广泛,且快速消除。
英文摘要:
      Objective To investigate the toxicokinetics and tissue distribution of Euptox A in rats.Methods 15 Wistar rats were randomly divided into 3 groups with 5 rats in each group.Blood samples were collected at different time points after intravenous injection of Euptox A 25, 50 and 100 mg·kg-1.The other 18 rats were randomly divided into 3 groups with 6 rats in each group.After intravenous injection of Euptox A 50 mg·kg-1, heart, liver, spleen, lung, kidney, brain, stomach, intestine, testis, muscle and blood samples were collected 10, 60 and 120 minutes later.The content of Euptox A in plasma and tissue was determined by high performance liquid chromatography.The toxicokinetic parameters were calculated by DAS 2.0 intelligent pharmacokinetic analysis software.Results After intravenous injection of Euptox A 25, 50 and 100 mg·kg-1, the toxicokinetics of rats accorded with the linear toxicokinetic characteristics.The average half-life were 27.4±6.7, 21.6±5.4, 18.3±5.8 min, the maximum blood concentration were 2.57±0.60, 5.83±0.94, 10.72±2.08 mg·L-1, the area under the curve were 2039.4±835.3, 4277.2±1194.6, 7842.7±1077.8 mg·min-1·L-1, respectively.10 minutes after the intravenous injection of Euptox A at a dose of 50 mg·kg-1, the content of Euptox A reached the highest level.After 60 minutes, the content of Euptox A decreased significantly.It is widely distributed in the body and higher in the blood, liver and heart.Conclusion Intravenous administration of Euptox A in rats conformed to the characteristics of linear toxicokinetics, which was widely distributed in rats and rapidly eliminated.
查看全文   查看/发表评论  下载PDF阅读器

分享按钮

漂浮通知

  X

近期,网上出现以《济宁医学院学报》杂志社的名义制造的虚假网站,诱骗作者在线投稿,骗取作者版面费或收取中介费,造成恶劣影响。在此提醒广大作者,审慎辨别,谨防上当。 投稿警示:我刊对所有来稿均不收取审稿费。 投稿方式:登录济宁医学院官方网站,在左下方点击“济宁医学院学报”进入《济宁医学院学报》网页,点击作者登录,注册新用户,然后在线投稿。