| 韩贵芝,顾宸铭,张丹丹,张正升,张兆强,林立.大蒜素对异丙肾上腺素诱导大鼠心肌缺血的保护作用[J].济宁医学院学报,2020,43(6):393-396 |
| 大蒜素对异丙肾上腺素诱导大鼠心肌缺血的保护作用 |
| The protective effect of allicin on isoprenaline-induced myocardial ischemia in rats |
| 投稿时间：2020-04-08 |
| DOI：10.3969/j.issn.1000-9760.2020.06.004 |
| 中文关键词: 大蒜素;缺血性心脏病;内皮素-1;降钙素基因相关肽 |
| 英文关键词: Allicin;Ischemic heart disease;ET-1;CGRP |
| 基金项目:山东省医药卫生科技发展计划项目（2017WS650，2017WS652）；济宁医学院大学生创新项目（cx2019021） |
| 作者 | 单位 | E-mail | | 韩贵芝 | 济宁医学院公共卫生学院, 济宁 272013 | | | 顾宸铭 | 济宁医学院公共卫生学院, 济宁 272013 | | | 张丹丹 | 济宁医学院公共卫生学院, 济宁 272013 | | | 张正升 | 济宁医学院附属济宁市第一人民医院, 济宁 272011 | 393177940@qq.com | | 张兆强 | 济宁医学院公共卫生学院, 济宁 272013 | | | 林立 | 济宁医学院公共卫生学院, 济宁 272013 | |
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| 中文摘要: |
| 目的 探讨大蒜素对大鼠心肌缺血的保护作用及其作用机制。方法 腹腔注射异丙肾上腺素建立大鼠心肌缺血损伤模型，将建模成功的大鼠随机分成模型组和大蒜素高、中、低剂量组，正常大鼠作对照组，每组10只。HE染色观察各组大鼠心肌纤维组织形态的变化，ELISA法检测各组血清中心肌酶的变化以及血清和心肌组织中CGRP和ET-l含量水平。结果 模型组大鼠心肌组织发生显著的病理学变化，AST、CK和LDH水平均高于对照组（均P<0.05）。与模型组相比，大蒜素低、中、高剂量组血清AST、CK和LDH水平显著降低（均P<0.05），心肌组织ET-1含量明显降低（F=9.590，P<0.05），CGRP含量明显升高（F=9.268，P<0.05）。大蒜素各剂量组大鼠心肌组织病理较模型组均有所改善。结论 大蒜素可降低大鼠心肌缺血模型血清心肌酶和心肌组织ET-1含量，增加心肌组织CGRP的表达，扩张心血管，增加供血量，减少心肌组织炎症损伤，保护心肌。 |
| 英文摘要: |
| Objective To explore the protective effect of allicin on myocardial ischemia in rats and its mechanism.Methods Isoproterenol was injected intraperitoneally to establish a rat model of myocardial ischemia injury.The successfully modeled rats were randomly divided into model groups, high, medium, and low dose allicin intervention groups, and normal rats as the control group, each with 10 rats.HE staining was used to observe the changes of rat myocardial fibrous tissue morphology of each group.The changes of serum myocardial enzymes and the levels of CGRP and ET-1 in serum and myocardial tissue were detected by ELISA.Results The myocardial tissue of the model group had significant pathological changes, and the levels of AST, CK and LDH were higher than those of the control group(P<0.05).Compared with the model group, the levels of AST, CK and LDH in the serum of the allicin groups were significantly reduced(P<0.05), the content of ET-1 in myocardial tissue was significantly reduced(F=9.590, P<0.05), and the content of CGRP was significantly increased high(F=9.268, P<0.05).The pathology of myocardial tissue of rats in each dose of allicin was improved compared with the model group.Conclusion Allicin can reduce serum myocardial enzymes and myocardial tissue ET-1 levels in rat myocardial ischemia model, increase the expression of CGRP in myocardial tissue, expand cardiovascular, increase the blood supply, slow down the inflammation damage in the myocardial tissue, and protect the myocardium. |
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