| 孔婧闻,韩惜惜,秦升,陈煜,魏超.益气活血化瘀法治疗慢性萎缩性胃炎的系统评价及Meta分析[J].济宁医学院学报,2020,43(5):305-311 |
| 益气活血化瘀法治疗慢性萎缩性胃炎的系统评价及Meta分析 |
| The systematic evaluation and meta analysis of the treatment of chronic atrophic gastritis with the method of supplementing Qi, activating blood circulation and removing blood stasis |
| 投稿时间：2020-07-09 |
| DOI：10.3969/j.issn.1000-9760.2020.05.001 |
| 中文关键词: 益气活血化瘀;慢性萎缩性胃炎;Meta分析;随机对照试验;中医药 |
| 英文关键词: Supplementing qi,activating blood circulation and removing blood stasis;Chronic atrophic gastritis;Meta analysis;Randomized controlled trial;Traditional Chinese medicine |
| 基金项目:中西医结合治疗脾胃病创新团队（18）；济宁医学院2018年度校级教育教学研究项目（18077）；山东省中西医结合临床重点学科项目（29） |
| 作者 | 单位 | E-mail | | 孔婧闻 | 济宁医学院中西医结合学院, 济宁 272067 | | | 韩惜惜 | 济宁医学院中西医结合学院, 济宁 272067 | | | 秦升 | 济宁医学院中西医结合学院, 济宁 272067 | | | 陈煜 | 济宁医学院中西医结合学院, 济宁 272067 | | | 魏超 | 济宁医学院中西医结合学院, 济宁 272067 | qw26010539@163.com |
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| 中文摘要: |
| 目的 通过Meta分析系统评价方法，评估益气活血化瘀法在治疗慢性萎缩性胃炎（chronic atrophic gastritis，CAG）的综合临床疗效，为临床治疗CAG提供更多的循证依据和可靠的理论基础。方法 检索CNKI、万方、维普、PubMed等数据库，收集自建库至2020年5月份正式发表的有关益气活血化瘀方药对比临床常规治疗方案治疗CAG的随机对照试验（randomized controlled trial，RCT）。“Cochrane偏倚风险评估”工具对所纳入的研究进行质量评价，采用Revman 5.3软件对符合条件的文献数据进行系统评价。结果 共纳入19个临床RCT，总样本1911例，其中试验组958例，对照组953例。选取临床疗效、胃镜疗效、Hp清除率、中医症状疗效等多项研究指标。Meta分析结果显示：在临床疗效方面中药试验组优于西药对照组（OR=3.43，95% CI=[2.65，4.44]，P<0.00001）；在Hp清除率方面，中药试验组优于西药对照组（OR=2.83，95% CI=[1.84，4.36]，P<0.00001）；在胃镜疗效方面，中药试验组优于西药对照组（OR=4.07，95% CI=[2.83，5.86]，P<0.00001）；在中医症状疗效等方面优于单纯应用西药常规治疗，差异均具有统计学意义（P<0.00001），且毒副作用相对较少。结论 益气活血化瘀法治疗CAG较单纯应用西药常规治疗临床疗效更好，值得应用推广。 |
| 英文摘要: |
| Objective To evaluate the comprehensive clinical efficacy of the method of supplementing qi,activating blood circulation and removing blood stasis in the treatment of chronic atrophic gastritis (CAG) by meta-analysis and systematic evaluation,so as to provide more evidence basis and reliable theoretical basis for clinical treatment of CAG.Methods The databases of CNKI,Wanfang,VIP and PubMed were searched to collect the randomized controlled trial (RCT) from the establishment of the database to May 2020.The Cochrane bias risk assessment tool was used to evaluate the quality of the included studies.Revman 5.3 software was used to systematically evaluate the eligible literature data.Results A total of 19 RCTs were included,including 958 cases in the experimental group and 953 cases in the control group.The clinical efficacy,gastroscope efficacy,HP clearance rate,TCM symptom efficacy and other research indicators were selected.The results of meta-analysis showed that:in terms of clinical efficacy,the Chinese medicine experimental group was better than the western medicine control group (OR=3.43,95%CI=[2.65,4.44],P<0.00001);in terms of HP clearance rate,the Chinese medicine experimental group was better than the Western Medicine control group (OR=2.83,95%CI=[1.84,4.36],P<0.00001);in the aspect of gastroscopy,the Chinese medicine experimental group was better than the western medicine control group (OR=4.07,95%CI=[2.83,5.86],P<0.00001);The difference was statistically significant (P<0.00001),and the side effects were relatively fewer.Conclusion The method of supplementing qi,activating blood circulation and removing blood stasis has better clinical efficacy than routine western medicine in the treatment of CAG,which is worthy of promotion. |
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