| 张波,苏衍华,庞丽艳,陈章良,李兆楼,王凤琴.卡拉胶/琼脂/羟丙基-β-环糊精复合凝胶的合成及其载药性能研究[J].济宁医学院学报,2020,43(4):242-247 |
| 卡拉胶/琼脂/羟丙基-β-环糊精复合凝胶的合成及其载药性能研究 |
| Synthesis of the hydrogel formed by carrageenan/Agar and hydroxypropyl-β-cyclodextrin and its controlled drug release |
| 投稿时间：2020-02-20 |
| DOI：10.3969/j.issn.1000-9760.2020.04.004 |
| 中文关键词: 卡拉胶;琼脂;羟丙基-β-环糊精;复合凝胶;体外释放;甲氨蝶呤 |
| 英文关键词: Carrageenan;Agar;Hydroxypropyl-β-cyclodextrin;Composite hydrogel;In vitro drug release;Methotrexate |
| 基金项目:济宁医学院教师科研扶持基金项目（JY2018KJ039）；济宁医学院大学生创新项目（cx2018047/201810443043） |
| 作者 | 单位 | E-mail | | 张波 | 济宁医学院基础医学院, 济宁 272067 | | | 苏衍华 | 济宁医学院药学院, 日照 276826 | | | 庞丽艳 | 济宁医学院药学院, 日照 276826 | | | 陈章良 | 济宁医学院临床医学院, 济宁 272013 | | | 李兆楼 | 济宁医学院基础医学院, 济宁 272067 | | | 王凤琴 | 济宁医学院基础医学院, 济宁 272067 | wfq2402370@163.com |
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| 中文摘要: |
| 目的 利用卡拉胶（KC）、琼脂（Agar）和羟丙基-β-环糊精（HP-β-CD）合成新型复合凝胶，探索其外观、微观结构、物理化学性质及载药性能。方法 采用溶胶-凝胶法合成KC/Agar/HP-β-CD复合凝胶，光学显微镜、扫描电子显微镜、红外光谱、X射线衍射（XRD）等观测其结构、性质、性能；载药凝胶包封率、体外释放等实验考察其对药物的缓控释作用。结果 制备了新型的KC/Agar/HP-β-CD复合凝胶及其载药凝胶，该凝胶性质稳定，载药凝胶包封率为50.29%；凝胶体系加入HP-β-CD，能使甲氨蝶呤载药凝胶的释药率降低约10%。结论 新型KC/Agar/HP-β-CD复合凝胶合成方法简便、成本较低，且对药物具有较高的包封率及明显缓控释作用。 |
| 英文摘要: |
| Objective A hydrogel formed by hydroxypropyl-β-cyclodextrin,carrageenan and Agar was synthesized,and its microstructure,morphology,physical properties and drug-carrying properties were further explored. Methods The sol-gel method was used to obtain the composite hydrogel,and the structure and properties of the gel sample were studied by optical microscope,scanning electron microscope,infrared spectroscopy,X-ray diffraction,differential thermal scanner and rheology.The sustained and controlled release effect of the composite hydrogel system on drug was verified by encapsulation rate and in vitro drug release assay. Results This composite hydrogel and its drug-carrying hydrogel were successfully obtained.The composite hydrogel can be stored for a long time.The encapsulation rate of drug methotrexate in the composite hydrogel was up to 50.29%.In vitro the drug release assay showed that addition of hydroxypropyl-β-cyclodextrin into the carrageenan-agar hydrogel could reduce the release rate of methotrexate by about 10%. Conclusion The composite hydrogel obtained showed high encapsulation rate and significant delay and control effect on drug methotrexate release. |
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