| 程纷纷,闫波.Sirtuins与冠心病[J].济宁医学院学报,2018,41(6):435-439 |
| Sirtuins与冠心病 |
| Sirtuins and coronary heart disease |
| 投稿时间：2018-06-07 |
| DOI：10.3969/j.issn.1000-9760.2018.06.015 |
| 中文关键词: Sirtuins家族;冠心病;应激;代谢 |
| 英文关键词: Sirtuins family;Coronary heart disease;Stress;Metabolism |
| 基金项目:国家自然科学基金资助项目（81370271） |
| 作者 | 单位 | E-mail | | 程纷纷 | 济宁医学院临床医学院, 济宁 272067
济宁医学院附属医院, 济宁 272029 | | | 闫波 | 济宁医学院临床医学院, 济宁 272067
济宁医学院附属医院, 济宁 272029 | yanbo@mail.jnmc.edu.cn |
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| 中文摘要: |
| 沉默信息调节因子（Sirtuins）家族是一类高度保守的第Ⅲ类去乙酰化酶，主要依赖烟酰胺腺嘌呤（NAD+）作为辅酶发挥其生物学功能。Sirtuins调控多种细胞过程，如基因转录、炎症反应、代谢、细胞应激等，并参与癌症、糖尿病、心血管疾病及神经性疾病等的发生发展。已有研究发现，Sirtuins可通过抗氧化、抗凋亡及抗炎等功能延缓冠心病的发生发展，在冠心病的发病中发挥重要作用。本文总结了近年来Sirtuins家族的研究进展，就其生物学功能和冠心病的相关性作一综述。 |
| 英文摘要: |
| Sirtuins family is a highly conserved class Ⅲ deacetylase,which mainly relies on nicotinamide adenine (NAD+) as a coenzyme.Sirtuins regulate a variety of cellular processes such as gene transcription,inflammation,metabolism,and cellular stress.And sirtuins has been participated in the development of cancer,diabetes,cardiovascular diseases and neurological diseases.It has been reported that sirtuins family can delay the progression of coronary heart disease through anti-oxidation,anti-apoptosis and anti-inflammatory functions.In this review,we summarize the recent progress on sirtuins family,focusing on the relationship between its biological functions and coronary heart disease. |
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