| 李树霞,孔庆暖,黄维清,甄宏伟,任永昌.PES1蛋白在乳腺癌组织中的表达及临床意义[J].济宁医学院学报,2018,41(3):180-184 |
| PES1蛋白在乳腺癌组织中的表达及临床意义 |
| The expression and clinical significance of PES1 protein in breast cancer |
| 投稿时间：2018-01-06 |
| DOI：10.3969/j.issn.1000-9760.2018.03.007 |
| 中文关键词: 乳腺癌;核仁蛋白;雌激素受体 |
| 英文关键词: Breast cancer;PES1;Estrogen receptor |
| 基金项目: |
| 作者 | 单位 | E-mail | | 李树霞 | 青岛大学医学院, 青岛 266000
临沂市中心医院, 沂水 276410 | | | 孔庆暖 | 青岛市立医院, 青岛 266000 | | | 黄维清 | 青岛市立医院, 青岛 266000 | 18678909697@163.com | | 甄宏伟 | 临沂市中心医院, 沂水 276410 | | | 任永昌 | 临沂市中心医院, 沂水 276410 | |
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| 中文摘要: |
| 目的 探讨核仁蛋白（Pescadillo，PES1）在乳腺癌组织中的表达，分析PES1与乳腺癌组织雌激素受体（estrogen receptor，ER）、孕激素受体（progesterone receptor，PR）及人表皮生长因子受体-2（human epidermal growth factor receptor-2，HER-2）间的关系，探讨其在乳腺癌发病机制及预后判断中的重要意义。方法 用免疫组织化学染色检测PES1蛋白在60例乳腺癌及癌旁组织中的表达，分析PES1蛋白在肿瘤组织中的表达水平以及与临床病理特征之间的关系，结合ER、PR、HER-2、Ki67 表达的水平分析PES1在乳腺癌发病机制中的作用。结果 PES1蛋白主要在乳腺癌组织的表达显著高于癌旁组织。PES1与ER表达具有关联性，与年龄、组织学类型、分级、分子分型及PR、HER-2、Ki67表达均无关。结论 PES1在乳腺癌肿瘤组织中高表达，与ER表达有关联，提示PES1可能通过激素通路参与乳腺癌的发病机制。 |
| 英文摘要: |
| Objective To investigate the expression of nucleolar protein (PES1,Pescadillo) in breast cancer tissue,and analyze the relationship among PES1,estrogen receptor (ER),progesterone receptor(PR) and human epidermal growth factor receptor-2(HER-2) in breast cancer.And then the significance in breast cancer pathogenesis and prognosis was eluciated.Methods The immunohistochemistry staining detection PES1 was used for the expression of 60 breast cancer and para-carcinoma tissue,and PES1's expression level in tumor tissue and relationship with clinicopathologic feature were analysed,as well as the role of PES1's in pathogenesis according to the expression level of ER,PR,HER-2 and Ki67.Results PES1's expression in breast cancer tissue was significantly greater than that in para-carcinoma tissue.It had correlation between PES1 and ER expression,while no any correlation was observed among age,histological type,classification,molecular subtyping and PR,HER-2,Ki67.Conclusion It indicates that PES1 may participate in breast cancer's pathogenesis through hormone pathways according to PES1's high expression in breast cancer tumor tissue and the positive correlation property of ER expression. |
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