| 高丽娜.Toll样受体4介导的巨噬细胞泡沫化与动脉粥样硬化[J].济宁医学院学报,2018,41(3):153-157 |
| Toll样受体4介导的巨噬细胞泡沫化与动脉粥样硬化 |
| Effects of Toll-like receptor 4 mediated macrophage foam cells in atherosclerosis |
| 投稿时间：2018-01-10 |
| DOI：10.3969/j.issn.1000-9760.2018.03.001 |
| 中文关键词: 动脉粥样硬化;巨噬细胞;Toll样受体;炎症;脂质代谢 |
| 英文关键词: Atherosclerosis;Macrophages;Toll-like receptors;Inflammation;Lipid metabolism |
| 基金项目:济宁医学院博士启动基金（2017JYQD06） |
| 作者 | 单位 | | 高丽娜 | 济宁医学院药学院, 日照 276826 |
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| 中文摘要: |
| 动脉粥样硬化斑块中占主导地位的固有免疫细胞是单核巨噬细胞。血脂升高和炎性因子表达增加刺激单核细胞活化为巨噬细胞，血管壁脂质过氧化导致脂质代谢障碍和炎症级联反应放大，形成泡沫细胞。动脉粥样硬化中，微环境信号可通过Toll样受体（TLRs）支配巨噬细胞的行为和结果，参与动脉粥样硬化的发生和发展。胆固醇晶体和修饰的脂蛋白也能直接作用于TLRs，促进巨噬细胞内脂质蓄积，加速动脉粥样硬化的发展。本文旨在综述TLR4活化介导巨噬细胞炎症反应和脂质代谢紊乱在动脉粥样硬化发病中的作用机制研究进展。 |
| 英文摘要: |
| The predominant innate immune cells in atherosclerotic plaques are mononuclear macrophages.Increased blood lipids and over-expression of inflammatory cytokines stimulate the activation of monocytes into macrophages.Lipid peroxidation in the vascular wall leads to lipid metabolism disorder and amplification of the inflammatory cascade,resulting in the formation of macrophage foam cells.In atherosclerosis,micro-environmental signals take part in the initiation and progression of atherosclerosis by controlling the behavior and results of macrophages via Toll-like receptors (TLRs).Cholesterol crystals and modified lipoproteins also act directly on TLRs,promoting lipid accumulation in macrophages and accelerating the development of atherosclerosis.In this manuscript,we aimed to review the advances of TLR4 activation mediated macrophage inflammatory response and lipid metabolism disorders in the pathogenesis of atherosclerosis. |
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