| 李丹丹,陈京.G蛋白偶联受体异源二聚化在抑郁症中的作用[J].济宁医学院学报,2017,40(6):420-424 |
| G蛋白偶联受体异源二聚化在抑郁症中的作用 |
| The role of G protein-coupled receptor heterodimerization in depression |
| 投稿时间：2017-09-20 |
| DOI：10.3969/j.issn.1000-9760.2017.06.009 |
| 中文关键词: G蛋白偶联受体;抑郁症;异源二聚化;治疗 |
| 英文关键词: G protein-coupled receptors;Depression;Heterodimerization;Therapy |
| 基金项目: |
| 作者 | 单位 | E-mail | | 李丹丹 | 曲阜师范大学, 曲阜 273165
济宁医学院神经生物研究所, 济宁 272067 | | | 陈京 | 曲阜师范大学, 曲阜 273165
济宁医学院神经生物研究所, 济宁 272067 | chenjnmc@163.com |
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| 中文摘要: |
| G蛋白偶联受体（G protein-coupled receptors，GPCRs）在人体中广泛表达，它所介导的信号转导在抑郁症的发生和发展中起到了非常重要的作用，是抗抑郁药物发挥药效的重要靶点。研究表明，GPCRs不仅以单体的形式存在，还可以以二聚体或高阶寡聚体的形式发挥作用。本文主要阐述了与抑郁症相关的GPCRs二聚体，以便更好地理解受体异源二聚体相互作用的分子机制，并为抑郁症的治疗提供更有效的方法。 |
| 英文摘要: |
| G protein-coupled receptors (G protein-coupled receptors,GPCRs) are widely expressed in the human body,the signal transduction of which plays a very important role in the occurrence and development of depression.So they are as a major target of antidepressant drugs.Studies have shown that GPCRs not only exist as monomers,but also act as dimers or higher order oligomers.This article focuses on GPCRs dimers which associated with depression in order to understand the molecular mechanisms of interactions between receptor-receptor heterodimers and exploits a more effective approach to the treatment of depression. |
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