文章摘要
武伟丽,李功迎.抑郁症快感缺失与多巴胺D3受体基因rs6280多态性的关联研究[J].济宁医学院学报,2017,40(5):338-341
抑郁症快感缺失与多巴胺D3受体基因rs6280多态性的关联研究
Association study of anhedonia with DRD3 genepolymorphism in patients with major depressive disorder
投稿时间:2017-07-12  
DOI:10.3969/j.issn.1000-9760.2017.05.007
中文关键词: 抑郁症;快感缺失;基因多态性
英文关键词: Depression;Anhedonia;Gene polymorphism
基金项目:国家自然科学基金面上项目(81571334);山东省研究生教育创新计划项目(SDYY 15012)。
作者单位E-mail
武伟丽 济宁医学院精神卫生学院, 济宁 272067  
李功迎 济宁医学院精神卫生学院, 济宁 272067 ligongying2005@126.com 
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中文摘要:
      目的 探讨抑郁症快感缺失与多巴胺D3受体(DRD3)基因多态性的关系。方法 以105例具有快感缺失的抑郁症患者为观察对象,95例身心健康的志愿者为对照,应用聚合酶链式反应(PCR)扩增技术和基因测序方法,检测DRD3rs6280分型,运用SPSS 22.0统计软件进行数据分析,验证各种基因型和等位基因与抑郁症快感缺失的关系。结果 观察组与对照组间DRD3基因的rs6280位点各基因型频率与等位基因频率,差异均无统计学意义(P>0.05);观察组间不同程度快感缺失患者基因型与等位基因分布,差异无统计学意义(P>0.05);不同基因型之间快感缺失SHAPS评分比较,差异无统计学意义(P>0.05)。结论 DRD3 rs6280单核甘酸多态性与抑郁症快感缺失无关。
英文摘要:
      Objective To explore the association between anhedonia and genepolymorphism of DRD3 in depressive patients.Methods 105 depressive disorder patients with anhedonia were studied and 95 mental healthy volunteers were acted as control group.Polymerase chain reaction(PCR) amplification technology and gene sequencing were used to detect the genotype of DRD3 rs6280.All data were analyzed by SPSS22.0 statistics software exploring the relationship between various genotypes and depression as well as alleles.Results There was no significant difference in the distribution of genotypes and alleles between observation group and control group on the rs6280 locus of DRD3 gene(P>0.05).After comparing the distribution of different genotypes and alleles between the high-degree anhedonia group and the low-degree group,there was no statistical significance on the locus of rs6280 in DRD3 gene(P>0.05).The significant difference in the degree of anhedonia was not found among different genotypes(P>0.05).Conclusion The genepolymorphism of DRD3 rs6280 was not associated with anhedonia in depression.
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