文章摘要
李开龙,徐华,王少春,陈东风.实时E成像在膜性肾病中的应用初探[J].济宁医学院学报,2017,40(2):118-121
实时E成像在膜性肾病中的应用初探
The basic research of the application of SWE in membranous nephropathy
投稿时间:2017-03-02  
DOI:10.3969/j.issn.1000-9760.2017.02.010
中文关键词: 膜性肾病;实时E成像;肾穿刺活检
英文关键词: Membranous Nephropathy;Shear Wave Elastography;Renal Biopsy
基金项目:
作者单位E-mail
李开龙 天津医科大学, 天津 300070  
徐华 济宁医学院附属医院, 济宁 272029  
王少春 济宁医学院附属医院, 济宁 272029  
陈东风 济宁医学院附属医院, 济宁 272029 jyfycdf@aliycm.com 
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中文摘要:
      目的 应用实时E成像观察膜性肾病(MN)患者肾实质杨氏模量值(YM)的变化,探讨E成像对MN的临床应用价值。方法 收集经肾穿刺活检证实为MN患者100例,并选取同期50例健康志愿者作为对照组。测量各受试者YM平均值,并同时检测Scr、BUN等生化指标以及MN患者24h尿蛋白量。比较两组YM及各指标的差异并分析其相关性。结果 MN患者YM及Scr、BUN等均较正常对照组升高,而血总蛋白、白蛋白及GFR较对照组低(P <0.05);YM与尿蛋白定量及胆固醇呈正相关(r=0.82,P<0.01;r=0.37,P<0.05),与GFR及白蛋白呈负相关(r=-0.49,P<0.01;r=-0.40,P<0.05)。结论 实时E成像可以反映肾脏组织弹性硬度,能够提供常规超声以外的信息,对膜性肾病有一定的应用价值。
英文摘要:
      Objective To study the application value of SWE in MN.Methods 100 patients with MN confirmed by renal biopsy and 50 healthy volunteers as control group were selected.The measurements were carried out including the YM and serum creatinine,urea nitrogen,and other laboratory parameters of each subject,and the 24h urinary protein quantitation in patients with MN.It was compared with the difference of YM and laboratory parameters in each group,and the correlation of them.Results The serum creatinine,urea nitrogen,cholesterol,triglycerides,LDL,lipoprotein (a) and YM were significantly higher while the total protein,albumin and glomerular filtration rate(GFR) were significantly lower in MN patients compared the control group(P<0.05).The YM and 24h urinary protein and cholesterol were positively correlated (r=0.82,P<0.01;r=0.37,P<0.05),while the YM and GFR and albumin were negatively correlated (r=-0.49,P<0.01;r=-0.40,P<0.05).Conclusion SWE can reflect the hardness kidney tissue,and provide additional information.This has some application value in MN.
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