| 张波,王启平,王慧云,全先高,王盈盈,王宁.正交实验优化甲氨蝶呤囊泡的制备[J].济宁医学院学报,2015,(4):247-250 |
| 正交实验优化甲氨蝶呤囊泡的制备 |
| Optimizing the preparation of methotrexate niosomes using the orthogonal test |
| 投稿时间：2015-06-15 |
| DOI：10.3969/j.issn.1000-9760.2015.04.005 |
| 中文关键词: 甲氨蝶呤|囊泡|包封率|正交实验 |
| 英文关键词: Methotrexate|Niosomes|Entrapment efficiency|Orthogonal test |
| 基金项目:济宁市科技局课题资助项目(编号:2009-19) |
| 作者 | 单位 | | 张波 | 济宁医学院基础学院, 山东济宁 272067 | | 王启平 | 济宁任城区卫生监督所, 济宁 272100 | | 王慧云 | 济宁医学院药学院, 山东日照 276826 | | 全先高 | 济宁医学院药学院, 山东日照 276826 | | 王盈盈 | 济宁医学院基础学院, 山东济宁 272067 | | 王宁 | 济宁医学院基础学院, 山东济宁 272067 |
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| 中文摘要: |
| 目的 制备甲氨蝶呤囊泡并通过正交实验优化甲氨蝶呤囊泡的制备工艺,探索最适宜的药物包封条件。方法 采用L9(34)正交法优化甲氨蝶呤囊泡对药物包封率的影响因素,以囊泡包封率为考察指标,确定最佳制备工艺条件。结果 司盘40(Span40)与胆固醇形成的囊泡(VSpan40:VCHOL=4:2),在50℃超声40 min的条件下,对0.60 g/L的甲氨蝶呤包封率最高,可达60%以上。结论 通过正交实验优化制得的甲氨蝶呤囊泡可获得较高的包封率。 |
| 英文摘要: |
| Objective The preparation process of the methotrexate niosomes were optimized by means of orthogonal experiment to explore the most suitable drug coating conditions.Methods The methotrexate encapsulation rate affecting factors was optimized by an L9(34)orthogonal test.The niosomes encapsulation rate as evaluation index was used to determine the best preparation program.Results The results showed that the entrapment efficiency of the niosomes prepared under the condition which were as follows:Span40 and cholesterol (VSpan40:VCHOL)was 2:1,the dosage of methotrexate,Ultrasonic temperature and time were 0.60g/L,50℃ and 40min,and the entrapment rate could reach more than 60%.Conclusion The methotrexate niosomes optimized by orthogonal test had a higher entrapment rate. |
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