| 李志华,王宇飞,韩捷,张惠,李春霞,马群.IL-23R基因多态性与桥本甲状腺炎关联性研究[J].济宁医学院学报,2014,(4):256-259 |
| IL-23R基因多态性与桥本甲状腺炎关联性研究 |
| Association between polymorphism of IL-23R and hashimoto thyroiditis |
| 投稿时间：2014-05-22 |
| DOI：10.3969/j.issn.1000-9760.2014.04.007 |
| 中文关键词: 桥本甲状腺炎;白介素;基因型;多态性 |
| 英文关键词: Hashimoto thyroiditis;Interleukin-23 receptor;Genotype;Polymorphism |
| 基金项目: |
| 作者 | 单位 | | 李志华 | 济宁医学院基础学院, 山东济宁 272067 | | 王宇飞 | 济宁医学院附属济宁市第一人民医院, 济宁 272011 | | 韩捷 | 济宁医学院附属济宁市第一人民医院, 济宁 272011 | | 张惠 | 济宁医学院基础学院, 山东济宁 272067 | | 李春霞 | 济宁医学院基础学院, 山东济宁 272067 | | 马群 | 济宁医学院基础学院, 山东济宁 272067 |
|
| 摘要点击次数: 5749 |
| 全文下载次数: 1404 |
| 中文摘要: |
| 目的 在中国山东籍汉族桥本甲状腺炎(hashimoto thyroiditis,HT)患者中,探讨白细胞介素受体(interleukin-23 receptor,IL-23R)基因多态性与HT的相关性,及其致病的分子生物学机制。方法 在145例HT患者和150名正常对照中,用限制性片段长度多态性分析的方法,对IL-23R基因的2个单核苷酸(rs17375018,rs7517847)多态性进行基因分型,分析单个位点的等位基因和基因型频率是否与HT相关。结果 在HT患者中,rs17375018 G的等位基因频率(P=0.013)和基因型频率(P=0.034)均超过正常对照组,差异有统计学意义;rs7517847的等位基因频率及基因型频率与正常对照组无显著性差异。结论 rs17375018基因多态性与HT存在显著的相关性,rs17375018基因可能增加HT的易感性。 |
| 英文摘要: |
| Objective To investigate the association between interleukin-23 receptor(IL-23R) gene polymorphism and hashimoto thyroiditis(HT) in Han population from Shandong province in china.Methods An correlation analysis was performed in a case-control cohort of 145 HT cases and 150 controls,and two SNPs located in the promoters of IL-23R gene(rs17375018,rs7517847) were examined by restriction fragment length polymorphism(RFLP).Statistics Product and Service Solutions(SPSS) software programs were used to calculate genotype and alleles frequencies and study the relationship between frequencies of genotype and alleles of the two sites and HT.Results The frequencies of allele G at positions 17375018 significantly increased in HT cases compared with control,so were their genotype frequencies.No association was found in HT and control in rs7517847.Conclusion Our study demonstrated that the HT is highly associated with polymorphism of rs17375018 in Chinese Han population.rs17375018 gene may play a role in HT susceptibility. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
|
|
|
