| 王少春,陈东风,曹长军,时克伟,田丽元.乳腺癌患者超声钼靶X线表现及分子生物学指标临床观察[J].济宁医学院学报,2013,(4):261-263,301 |
| 乳腺癌患者超声钼靶X线表现及分子生物学指标临床观察 |
| Clinical research on ultrasonographic and mammographic features and molecular biology of breast cancer |
| 投稿时间：2013-03-22 |
| DOI：10.3969/j.issn.1000-9760.2013.04.009 |
| 中文关键词: 乳腺癌;超声;钼靶X线;分子生物学 |
| 英文关键词: Breast cancer, Ultrasonography, Mammography, Molecular biology |
| 基金项目:山东省教育厅资助经费项目(项目编号:J09LF26) |
| 作者 | 单位 | | 王少春 | 济宁医学院附属医院, 山东济宁 272029 | | 陈东风 | 济宁医学院附属医院, 山东济宁 272029 | | 曹长军 | 济宁医学院附属医院, 山东济宁 272029 | | 时克伟 | 济宁医学院附属医院, 山东济宁 272029 | | 田丽元 | 济宁医学院附属医院, 山东济宁 272029 |
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| 中文摘要: |
| 目的 探讨乳腺癌患者超声、钼靶X线表现与分子生物学指标ER、PR、CerbB-2的临床变化特征。方法 回顾性观察分析137例病理确诊为乳腺癌的术前超声及钼靶特点,并分析与分子生物学指标ER、PR、CerbB-2的关系。结果 1)超声:肿块有毛刺征、晕征、纵横比≥1组ER、PR阳性率高于无毛刺、无晕,纵横比< 1组;周边有晕组CerbB-2阴性率高于无晕组;有钙化组CerbB-2阳性率高于无钙化组;肿块内部发生坏死组PR阴性率高于无坏死组。2)钼靶:肿块伴钙化组ER阳性率高于其它3种类型;有钙化组CerbB-2阳性率高于无钙化组;边界不清晰组ER、PR阳性率高于无此征象组。结论 乳腺癌超声及钼靶表现与分子生物学指标存在一定的关系,其影像学征象可预测肿瘤的生物学行为。 |
| 英文摘要: |
| Objective To investigate the correlation clinical characteristics between the ultrasonographic and mammographic features with molecular biology such as ER, PR and CerbB-2 of breast cancer.Methods The ultrasonographic and mammographic features of 137 cases of breast cancer confirmed by histopathology were analyzed retrospectively.The indexes of ultrasonic main observation were as following:lump size, shape, internal echo, aspect ratio, halo edge and burr sign, blood flow, calcification and lymph node metastasis.The indexes of mammographic main observation were as following:breast cancer patients, lesion type, mass density, calcification and boundaries, and it was analysed the relationship with ER, PR and CerbB-2.Results 1) About the ultrasonographic features, ER and PR positive rate in tumors had spiculate margin and the boundary halo, length and breadth rate≥1 was higher than the group without spiculate margin, boundary halo and breadth rate1;CerbB-2 negative rate tumors with boundary halo was higher than the group without boundary halo;CerbB-2 positive rate in tumors with calcification was higher than the group without calcification;PR negative rate in tumors with internal necrosis was higher than the group without internal necrosis.2) About the mammographic features, ER positive rate in mass with calcification was higher than other three types;CerbB-2 positive rate in tumors with calcification was higher than the group without calcification;ER and PR positive rate in tumors with indistinct boundary was higher than the group without this sigh.Conclusion There are some correlations between breast cancer ultrasonographic and mammographic features.The imaging features can assess the biologic behavior. |
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