| 丁韶峰,杨星林,孙凤娟.艾塞那肽联合甘精胰岛素治疗肥胖2型糖尿病临床观察[J].济宁医学院学报,2013,(1):31-33 |
| 艾塞那肽联合甘精胰岛素治疗肥胖2型糖尿病临床观察 |
| Efficacy of exenatide combined with insulin glargine in newly diagnosed type 2 diabetes patients with obesity |
| 投稿时间：2012-12-05 |
| DOI：10.3969/j.issn.1000-9760.2013.01.008 |
| 中文关键词: 2型糖尿病;艾塞那肽;甘精胰岛素;肥胖 |
| 英文关键词: Type 2 diabetes mellitus;Exenatide;Insulin glargine;Obesity |
| 基金项目: |
| 作者 | 单位 | | 丁韶峰 | 济南大学山东省医学科学院医学与生命科学学院, 山东济南 250062
济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 杨星林 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 孙凤娟 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 |
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| 中文摘要: |
| 目的 探讨容积导体对离体蟾蜍心电的影响。方法 离体蟾蜍心脏置培养皿中央,培养皿内加入林格氏液,在培养皿周边置电极记录心电。结果 心电图R波幅度随心脏周围容积导体的增大明显减小。容积导体由1ml增大到5ml,R波幅度即明显减小,由(0.99±0.12)mV减小到(0.53±0.06)mV,减小46.5%;当容积导体增大到30ml时,R波减小94.9%。结论 心电图受心脏周围容积导体或组织液量的影响。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of exenatide combined with insulin glargine in newly diagnosed type 2 diabetes patients with obesity.Methods 30 cases of newly diagnosed T2DM patients with obesity were treated with exenatide and insulin glargine for 24 weeks.Self-control study was used to evaluate the changes in blood glucose,glycosylated hemoglobin (HbAlc),C peptide,blood pressure,lipids and body mass index (BMI).Results Levels of fasting plasma glucose (FPG),postprandial 2h plasma glucose (2hPG),HbAlc,BMI,systolic blood pressure (SBP),triglycerides (TG),total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were significantly decreased.On the other hand,the fasting C-peptide (F-CP),2h postprandial C-peptide (2h-CP) was increased obviously (P<0.01).Conclusion The therapy with exenatide and insulin glargine insulin could effectively control blood glucose,significantly improve β-cell functionin and reduce weight in newly diagnosed T2DM patients with obesity.Key words:Type 2 diabetes mellitus;Exenatide;Insulin glargine;Obesity |
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