| 李岩,孙晓斐,丛培玲,徐勤成,魏子秀.阿卡波糖联合二甲双胍对糖耐量减低冠心病患者的干预作用[J].济宁医学院学报,2013,(1):28-30,33 |
| 阿卡波糖联合二甲双胍对糖耐量减低冠心病患者的干预作用 |
| Effect of acarbose and metformin treatment in patients with coronary heart disease accompanied by impaired glucose tolerance |
| 投稿时间：2012-12-01 |
| DOI：10.3969/j.issn.1000-9760.2013.01.007 |
| 中文关键词: 阿卡波糖;二甲双胍;糖耐量异常;冠状动脉粥样硬化性心脏病 |
| 英文关键词: Acarbose;Metformin;Impaired glucose tolerance;Coronary atherosclerotic heart disease |
| 基金项目: |
| 作者 | 单位 | | 李岩 | 济南大学山东省医学科学院医学与生命科学学院, 山东济南 250062
济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 孙晓斐 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 丛培玲 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 徐勤成 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 魏子秀 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 |
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| 中文摘要: |
| 目的 探讨新西兰大白兔动脉粥样硬化病变中血管细胞黏附因子-1(VCAM-1)的表达和青心酮抗动脉粥样硬化作用。方法 18只新西兰大耳白兔随机分为常规饲料组、胆固醇饲料组和青心酮组,饲养12周。实验前后检测血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL),采用免疫组化和Western blot法测定主动脉VCAM-1阳性表达百分比和蛋白的表达。结果 青心酮显著降低TC、TG和LDL水平(P<0.05)。胆固醇组和青心酮组病变局部VCAM-1的阳性细胞百分比和蛋白的表达含量明显高于常规饲料组(P<0.05)。但青心酮组动脉粥样硬化改变较胆固醇组明显减轻,VCAM-1阳性百分比和蛋白的表达量较胆固醇饲料组明显降低(P<0.05)。结论 动脉粥样硬化的发生伴有血管细胞黏附因子的高度表达,青心酮不但有调脂作用,且具有抑制黏附分子表达和抗动脉粥样硬化的作用。 |
| 英文摘要: |
| Objective To evaluate the effect of small dose of metformin and acarbose on cardiovascular events in patients with coronary heart disease combined with impaired glucose tolerance.Methods It was selected by coronary angiography confirmed 324 cases of patients of coronary heart disease merged with impaired glucose tolerance.Randomly they were divided into acarbose,metformin group,the combined treatment group and the control group,81 cases in each group.The control group were given basic treatment,and the remaining three groups were given drug treatment on the basis of the basic treatment.Results After 6 months of follow-up,the drug treatment group cardiovascular events were significantly lower than the control group(P<0.05).The incidence of cardiovascular events was no significant difference between the drug treatment group(P>0.05).Conclusion Acarbose and metformin Treatment can significantly reduce the incidence of cardiovascular events in patients of coronary heart disease merged with impaired glucose tolerance.Impact on cardiovascular events in patients is no significant difference between the combination therapy with a single drug.Key words:Acarbose;Metformin;Impaired glucose tolerance;Coronary atherosclerotic heart disease |
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