| 张艳玲,张艳英,岳伟华.MTHFR基因C677T多态性与精神分裂症患者发病年龄及抗精神病药疗效的关联研究[J].济宁医学院学报,2012,(6):382-386 |
| MTHFR基因C677T多态性与精神分裂症患者发病年龄及抗精神病药疗效的关联研究 |
| Association of MTHFR C677T polymorphism with age at onset of schizophrenia and therapeutic effects of antipsychotics |
| 投稿时间：2012-12-05 |
| DOI：10.3969/j.issn.1000-9760.2012.06.001 |
| 中文关键词: 精神分裂症;MTHFR基因;发病年龄;抗精神病药 |
| 英文关键词: Schizophrenia;MTHFR;Age at onset;Antipsychotics |
| 基金项目:国家自然科学基金资助项目(编号:81071087),北京市科技新星计划(编号:2009A03) |
| 作者 | 单位 | E-mail | | 张艳玲 | 北京大学精神卫生研究所, 北京 100191
卫生部精神卫生学重点实验室, 北京 100191
北京航天总医院, 北京 100076 | | | 张艳英 | 临沂市精神卫生中心, 山东临沂 276000 | | | 岳伟华 | 北京大学精神卫生研究所, 北京 100191
卫生部精神卫生学重点实验室, 北京 100191 | dryue@bjmu.edu.cn |
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| 中文摘要: |
| 目的 探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与精神分裂症发病年龄及抗精神病药疗效的关联。方法 以首次出现精神症状作为精神分裂症患者发病年龄,采用简明精神症状评定量表(Brief psychiatric rating scale,BPRS)减分率评估抗精神病药的疗效,采用测序方法检测MTHFR基因C677T基因型。结果 MTHFR基因C677T多态性对精神分裂症发病年龄有显著性的影响(ANOVA,P=0.039),TT基因型携带者的发病年龄较CC携带者的发病年龄小。进一步分析发现男性患者发病年龄早于女性(ANOVA,P=0.004),且该基因多态性对发病年龄的影响主要体现在女性患者中(ANOVA,P=0.013;Plog rank=0.023)。MTHFR基因C677T多态性与精神分裂症抗精神病药物疗效(BPRS减分率)之间并无显著关联。结论 MTHFR基因C677T多态性与精神分裂症尤以女性患者的发病年龄显著关联,可能是精神分裂症的高风险致病基因之一。 |
| 英文摘要: |
| Objective To explore the association of methylenetetrahydrofolate reductase(MTHFR) C677T polymorphism with the age at onset of schizophrenia or the therapeutic effects of antipsychotics.Methods We defined the age at onset of schizophrenia as the age of first episode of psychiatric symptoms according to participants' medical record.The main efficacy assessment was evaluated by brief psychiatric rating scale(BPRS).Results The MTHFR C677T polymorphism significantly affected age at onset of schizophrenia in a dose-dependent manner(ANOVA, P=0.039), the average onset of schizophrenia was earlier in subjects with TT genotype than subjects with CC genotype.The average onset of schizophrenia was later in women than men(P=0.004).Further analysis demonstrate that C677T polymorphism affected age at onset of schizophrenia only in women(P=0.013;Plog rank=0.023).There was no significant association between MTHFR C677T polymorphism and BPRS reduced rate.Conclusion The MTHFR C677T polymorphism was associated with age at onset of schizophrenia but not with therapeutic effects of antipsychotics. |
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