| 丛晓荣,秦景梅,史孝玲.溶栓治疗时间对急性心肌梗死患者心功能的影响[J].济宁医学院学报,2012,(4):259-261 |
| 溶栓治疗时间对急性心肌梗死患者心功能的影响 |
| The effects of thrombolytic time on the left ventricular function of the patients with actue myocardial infarction |
| 投稿时间：2012-05-21 |
| DOI：10.3969/j.issn.1000-9760.2012.04.009 |
| 中文关键词: 急性心肌梗死;溶栓时间;心功能 |
| 英文关键词: Actue myocardial infarction;Thrombolytic time;Left ventricular function |
| 基金项目: |
| 作者 | 单位 | | 丛晓荣 | 滕州市中心人民医院, 山东滕州 277500 | | 秦景梅 | 滕州市中心人民医院, 山东滕州 277500 | | 史孝玲 | 滕州市中心人民医院, 山东滕州 277500 |
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| 中文摘要: |
| 目的 旨在探讨溶栓治疗时间对急性心肌梗死患者心功能的影响。方法 符合AMI诊断标准的84例患者按溶栓距发病时间分为3组:早期静脉溶栓组、延迟静脉溶栓组、晚期静脉溶栓组,未接受溶栓者为对照组。分别于AMI急性期及恢复期测定血浆脑利钠肽(BNP)及左室射血分数(LVEF)。结果 1)急性期早期溶栓组、延迟溶栓组BNP及LVEF与对照组比较,差异均有统计学意义,晚期溶栓组BNP及LVEF与对照组比较,差异无统计学意义;恢复期早期溶栓组、延迟溶栓组BNP与对照组比较,差异均有统计学意义,晚期溶栓组BNP与对照组比较,差异无统计学意义;恢复期早期溶栓组、延迟溶栓组、晚期溶栓组LVEF与对照组比较,差异均有统计学意义。2)相关分析显示溶栓治疗时间与恢复期BNP值呈正相关(r=-0.62,P<0.05),与LVEF呈负相关(r=-0.73,P<0.05)。结论 冠状动脉阻塞时间越长,心室功能恢复越延迟;早期实行静脉溶栓治疗,能挽救濒死心肌,保护左心室功能,降低死亡率。 |
| 英文摘要: |
| Objective To explore the effects of thrombolytic time on the left ventricular function of the patients with actue myocardial infarction(AMI).Methods 84 patients with AMI were divided into three groups according to the time of admission to thrombolytic therapy:the early thrombolytic group, the delayed thrombolytic group, the late thrombolytic group. The patients with non-thrombolytic therapy were the control group. Peripheral blood samples were taken at acute and convalescent period for plasma brain natriuretic peptide(BNP) and left ventricular function(LVEF).Results 1) At acute period, compared with the control group, the BNP level and LVEF in the early thrombolytic group and the delayed thrombolytic group had statistical significance. The late thrombolytic group had no statistical significance compared the control group. At convalescent period, compared with the control group, the BNP level of the early thrombolytic group and the delayed thrombolytic group had statistical significance. The late thrombolytic group had no statistical significance compared the control group. At convalescent period, compared with the control group, the LVEF of the three thrombolytic groups had statistical significance.2)The Pearson analysis showed that the time of admission to thrombolytic therapy was positively correlated with the BNP level at convalescent period(r=0.62, P<0.05), and negatively correlated with LVEF(r=-0.73, P<0.05).Conclusion The longer the time of occlusion in coronary artery, the later the recovery of left ventricular function. The study showed that the early intravenous thrombolytic therapy could retrieve on the brink of necrotic myocardium, conserve left ventricular function and reduce the ratio of death. |
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