文章摘要
王瑜,曹玉杰,刘秀霞,蔡文仙,牛峰海,朱萍.重症手足口病患儿血清神经元特异性烯醇化酶的变化[J].济宁医学院学报,2011,(4):250-251,275
重症手足口病患儿血清神经元特异性烯醇化酶的变化
Change of serum neuron-specific enolase level in children with severe hand-foot-mouth disease
投稿时间:2011-07-05  
DOI:10.3969/j.issn.1000-9760.2011.04.007
中文关键词: 手足口病;神经元特异性烯醇化酶;静脉滴注免疫球蛋白;小儿危重病例评分
英文关键词: hand-foot-mouth disease;neuron-specific enolase;intravenous immunoglobulin;pediatric critical illness scores
基金项目:济宁市科技局课题济科字[2009]56号
作者单位
王瑜 济宁医学院附属医院, 山东济宁 272029 
曹玉杰 济宁医学院附属医院, 山东济宁 272029 
刘秀霞 济宁医学院附属第一人民医院, 山东济宁 272011 
蔡文仙 济宁医学院附属医院, 山东济宁 272029 
牛峰海 济宁医学院附属医院, 山东济宁 272029 
朱萍 济宁医学院附属医院, 山东济宁 272029 
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中文摘要:
      目的 研究重症手足口病患儿血清神经元特异性烯醇化酶的变化,为治疗提供科学依据。方法 收集2009年4月至2009年6月收治的手足口病患儿40例,单纯隐睾或斜疝儿童20例。分为手足口病普通病例组20例,手足口病重症病例组20例和对照组20例。手足口病重症病例组出现神经系统受累,但无心肺功能损害。入院第1天及第2天分别予静脉滴注免疫球蛋白(IVIG)1 g/(kg.d)。用ELISA方法检测血清神经元特异性烯醇化酶(NSE)含量。手足口病重症病例组入院第1天行小儿危重病例评分(PCIS)。结果 手足口病普通病例组,手足口病重症病例组治疗前,手足口病重症病例组治疗后,对照组NSE含量分别为6.95±1.57 ng/ml,8.80±2.24 ng/ml,8.00±1.97 ng/ml,6.60±1.70 ng/ml。手足口病重症病例组血清NSE含量高于手足口病普通病例组和对照组。IVIG治疗前后血清NSE水平比较差别无统计学意义(P>0.05)。PCIS与NSE水平明显相关(r=0.530,P<0.05)。结论 重症手足口病患儿血清NSE水平与可反映疾病严重程度。
英文摘要:
      Objective To study the change of serum neuron-specific enolase level in children with severe hand-foot-mouth disease and provide scientific basement for treatment.Methods 40 children with hand-foot-mouth disease(HFMD) and 20 children with simply cryptorchidism or hernia were investigated from April to June in 2009 in the research.They were divided into three groups:common HFMD group(n=20),severe HFMD group(n=20) and control group(n=20).Children with severe HFMD involved nervous system without cardiopulmonary function damage,and they received intravenous immunoglobulin(IVIG) at a dosage of 1 g/(kg.d) respectively on the first and next day after admission.The level of NSE was detected by enzyme-linked immunosorbent assay.Pediatric critical illness scores(PCIS)were completed on first day after admission in the severe HFMD group.Results The levels of NSE in common HFMD group,severe HFMD group before IVIG,severe HFMD group after IVIG and control group were 6.95±1.57ng/ml,8.80±2.24ng/ml,8.00±1.97ng/ml and 6.60±1.70ng/ml respectively.The level of NSE in severe HFMD group were higher than that in control group and common HFMD group(P<0.01).There was no significant difference on the levels of NSE before and after IVIG(P>0.05).PCIS was significantly positively correlated with NSE(r=0.530,P<0.05).Conclusion The serum level of NSE could reflect the severity of HFMD.
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