| 刘增甲,崔文,王旭,张国安,张学海,孙德丁.EV71致重症手足口病患儿脑损伤的病理机制研究[J].济宁医学院学报,2011,(3):167-168,171 |
| EV71致重症手足口病患儿脑损伤的病理机制研究 |
| The pathological mechanism of the brain damage in children with the severe HFMD induced by EV71 |
| 投稿时间：2011-05-15 |
| DOI：10.3969/j.issn.1000-9760.2010.06.006 |
| 中文关键词: EV71|HFMD|尸体检验|嗜神经细胞现象 |
| 英文关键词: EV71|HFMD|autopsy|Eosinophilic neural phenomenon |
| 基金项目:济宁市科技局2010年重点资助项目 |
| 作者 | 单位 | E-mail | | 刘增甲 | 济宁医学院基础医学与法医学院, 山东济宁 272067 | | | 崔文 | 济宁医学院基础医学与法医学院, 山东济宁 272067 | cuiwenmd@sina.com | | 王旭 | 济宁医学院基础医学与法医学院, 山东济宁 272067 | | | 张国安 | 济宁医学院基础医学与法医学院, 山东济宁 272067 | | | 张学海 | 济宁市传染病院, 山东济宁 272031 | | | 孙德丁 | 济宁医学院附属第一人民医院, 山东济宁 272011 | |
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| 中文摘要: |
| 目的 观察新肠道病毒(EV71)致脑组织损伤的病理学变化。方法 对7例EV71引起的重症手足口病(HFMD)死亡患儿进行尸体检验并对其脑组织进行HE染色,观察其主要组织病理学改变。结果 患儿口腔及四肢可见淡红色圆形或椭圆形疱疹;脑组织以脑干、延髓为中心见大量软化灶及神经细胞卫星现象和嗜神经细胞现象;神经胶质细胞大量增生及多个胶质细胞结节形成。结论 EV71可引起严重的脑组织损伤,以脑干、延髓最为严重。 |
| 英文摘要: |
| Objective To investigated the pathology of the brain injury induced by the new intestinal virus(EV71).Methods The autopsy was from 7 dead children with the severe hand-foot-and-mouth disease and the brain tissue was dyed for HE.The major histopathologic changes were observed.Results Pink round and oval herpes could be found around the oral cavity and limbs of the children.Focal malacoma, satellite cells and neurotrophic phenomenon were observed in the brain especially the brainstem and Medulla oblongata.Glial hyperplasia and the formation of glial nodule were also found.Conclusion EV71 can result in severe brain damage especially in the brainstem and medulla oblongata. |
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