| 马健博,陈章良,吕京纭,李慧金,董奕宸,罗家晔,陶李熹,张波.羧甲基纤维素钠/丙烯酰胺/Mg-Al LDH纳米水凝胶的制备及其pH敏感性研究[J].济宁医学院学报,2025,48(2):129-133 |
| 羧甲基纤维素钠/丙烯酰胺/Mg-Al LDH纳米水凝胶的制备及其pH敏感性研究 |
| Preparation and pH sensitivity of sodium carboxymethyl cellulose/acrylamide/Mg-Al LDH nanohydrogel |
| 投稿时间：2024-01-26 |
| DOI：10.3969/j.issn.1000-9760.2025.02.007 |
| 中文关键词: 水凝胶;层状双金属化合物;纳米复合材料;pH敏感性;溶胀比;药物载体 |
| 英文关键词: Hydrogel;Layered bimetallic compound;Nanocomposite;PH sensitivity;Swelling ratio;Drug carrier |
| 基金项目:济宁医学院大学生创新项目(cx2023104z) |
| 作者 | 单位 | E-mail | | 马健博 | 济宁医学院附属医院(临床医学院), 济宁 272067 | | | 陈章良 | 锦州医科大学抚顺市中心医院研究生培养基地, 抚顺 113006 | | | 吕京纭 | 济宁医学院附属医院(临床医学院), 济宁 272067 | | | 李慧金 | 济宁医学院附属医院(临床医学院), 济宁 272067 | | | 董奕宸 | 济宁医学院附属医院(临床医学院), 济宁 272067 | | | 罗家晔 | 济宁医学院附属医院(临床医学院), 济宁 272067 | | | 陶李熹 | 济宁医学院附属医院(临床医学院), 济宁 272067 | | | 张波 | 济宁医学院附属医院(临床医学院), 济宁 272067 | jyzb1224@163.com |
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| 中文摘要: |
| 目的 制备羧甲基纤维素钠/丙烯酰胺/Mg-Al LDH纳米水凝胶(简称纳米水凝胶),并探讨其在不同pH值条件下的溶胀率。方法 以丙烯酰胺,羧甲基纤维素(CMC),层状双金属化合物(LDH)为原料,过氧二硫酸铵(APS)为引发剂,亚甲基双丙烯酰胺(MBA)为交联剂,通过自由基结合的方法合成水凝胶,并采用傅里叶红外分光光度计进行表征,采用接触角测定仪测定了水凝胶的接触角,并通过在不同pH值水溶液中的溶胀试验,测定其溶胀率。结果 制备纳米水凝胶的最佳条件是2 g CMC,0.2 g LDH,1 g丙烯酰胺,0.4 g APS,0.08 g MBA,在此条件下制备的纳米水凝胶具有最大溶胀率,pH敏感性实验显示,合成的水凝胶在pH=8时溶胀率最高。结论 羧甲基纤维素钠/丙烯酰胺/Mg-Al LDH纳米水凝胶作为药物载体对药物在不同PH值下的释放有一定的指导意义。 |
| 英文摘要: |
| Objective To prepare sodium carboxymethyl cellulose/acrylamide/Mg-Al LDH nanohydrogel and study their swelling ratios at different pH values. Methods The nano hydrogels was synthesized with acrylamide (AM),carboxymethyl cellulose (CMC) and layered bimetallic compounds as raw material,ammonium peroxydisulfate (APS) as initiator,and methylene bisacrylamide (MBA) as crosslinking agent,by free radical binding,and it was characterized by the Fourier infrared spectrophotometer.The contact Angle of hydrogle measured by contact Angle tester,and swelling rate was determined by swelling test in aqueous solutions of different pH values. Results The optimum conditions for preparing nano hydrogels were 2 g CMC,0.2 g LDH,1 g acrylamide,0.4 g APS,0.08 g MBA,and the nanosels prepared under these conditions had the maximum swelling rate.The maximum swelling rate of the synthesized hydrogel was at pH=8 under the conditions of different pH values. Conclusion Carboxymethyl polyacrylamide Mg-Al LDH nano hydrogel as drug carrier has certain guiding significance for the release of drugs at different pH values. |
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