|
| 临床药师参与抗凝管理对非瓣膜性房颤患者口服华法林抗凝效果的影响 |
| To investigate the effect of clinical pharmacists participating in anticoagulation management on oral warfarin anticoagulation in patients with non-valvular atrial fibrillation |
| 投稿时间：2023-09-18 修订日期：2024-05-15 |
| DOI： |
| 中文关键词: 非瓣膜房颤；华法林；抗凝剂；药物治疗效果；监护管理 |
| 英文关键词: Non-valvular atrial fibrillation;Warfarin; Anticoagulation Drug;adherence Monitoring;ManagementManagement |
| 基金项目: |
| 作者 | 单位 | 邮编 | | 杨培民* | 淄博市市立医院 | 255400 |
|
| 摘要点击次数: 33 |
| 全文下载次数: 0 |
| 中文摘要: |
| 摘要 目的 本研究旨在探讨对非瓣膜性房颤患者口服华法林的过程中有临床药师参与抗凝管理对抗凝效果的影响，有效地提高非瓣膜性房颤住院患者口服华法林的依从性，降低口服华法林的不良事件发生率。方法 我们从2019年1月至2020年9月收治的132例非瓣膜性房颤患者中随机抽取66例作为观察组，由临床药师、护士和住院医生联合抗凝管理，另外66例作为对照组，由住院医生、主管护士在住院期间进行常规抗凝管理，试验组在对照组的基础上，接受临床药师抗凝药物监护的干预，以探究华法林抗凝管理的效果和安全。结果 观察组患者的 INR 达标率高于对照组，差异有统计学意义（χ2=3.86，P﹤0.05）；观察组患者服用华法林的依从性（89.39%）优于对照组（57.56%），差异具有统计学意义（χ2=17.94，P﹤0.001）；出血性事件发病率观察组（9.09%）则小于对照组（31.38%），差异具有统计学意义（χ2=4.59，P<0.05）。结论 临床药师参与抗凝管理服务可以显著提升非瓣膜房颤患者抗凝效果与安全，因此，应当加强临床药师对抗凝防治的监护管理服务。 |
| 英文摘要: |
| Abstract Objective To explore the effect of clinical pharmacists' participation in anticoagulation management on the anticoagulation effect of oral warfarin in patients with non-valvular atrial fibrillation, so as to effectively improve the compliance of oral warfarin in hospitalized patients with non-valvular atrial fibrillation and reduce the incidence of adverse events of oral warfarin. Methods From 132 patients with non-valvular atrial fibrillation admitted to our hospital from January 2019 to September 2020, 66 cases were randomly selected as the observation group, which was managed by clinical pharmacists, nurses and residents. The other 66 cases were selected as the control group, which was managed by residents and nurses during hospitalization, and the experimental group was treated with routine anticoagulation management on the basis of the control group. The intervention of anticoagulant drug monitoring by clinical pharmacists was conducted to explore the effect and safety of warfarin anticoagulation management. Results The INR compliance rate of the observation group patients is higher than that of the control group, and the difference is statistically significant（χ2=3.86, P<0.05); The compliance of patients taking warfarin in the observation group (89.39%) was better than that in the control group (57.56%), and the difference was statistically significant（χ2=17.94, P<0.001); The incidence rate of bleeding events in the observation group (9.09%) was lower than that in the control group (31.38%), with a statistically significant difference（χ2=4.59, P<0.05). Conclusion The INR standard rate of the observation group was significantly higher than that of the control group, and the difference between the two groups was statistically significant(P<0.05); The participation of clinical pharmacists in anticoagulation management service can significantly improve the efficacy and safety of anticoagulation in patients with NVAF. Therefore, it is necessary to strengthen the monitoring and management service of clinical pharmacists for anticoagulation prevention and treatment. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
