|
MCP-1在2型糖尿病中的作用研究进展 |
Advances in the study of the role of MCP-1 in type 2 diabetes mellitus |
投稿时间:2023-05-15 修订日期:2024-02-29 |
DOI: |
中文关键词: 糖尿病、MCP-1、CCL2、糖尿病肾病、免疫 |
英文关键词: Diabetes, MCP-1, CCL2, diabetic nephropathy, immunity |
基金项目: |
作者 | 单位 | 邮编 | 孙丽华 | 济宁医学院临床医学院 | 272002 | 胡芳志 | 济宁市第一人民医院内分泌与代谢科 | |
|
摘要点击次数: 0 |
全文下载次数: 0 |
中文摘要: |
摘要:2型糖尿病(T2DM)是一种常见的内分泌慢性代谢性疾病,其发病率逐年升高,呈现年轻化的趋势,且长期慢性高血糖易引起多种并发症,影响人类的生活质量,已成为严重危害人类生命健康的疾病,但对于其发病机制目前尚不明确。单核细胞趋化蛋白-1(monocyte chemotactic protein 1, MCP-1)作为CC趋化因子家族中的一员,参与多种自身免疫性疾病的发生发展,目前已有的研究结果显示,MCP-1与T2DM并发症中的大血管、微血管病变及神经相关联,可能参与其发病机制之中,本文就MCP-1在2型糖尿病及其并发症中的研究进展作一论述。 |
英文摘要: |
Type 2 diabetes mellitus (T2DM) is a common endocrine chronic metabolic disease, the incidence of which is increasing year by year, presenting a trend of rejuvenation, and long-term chronic hyperglycemia is prone to cause a variety of complications, which affects the quality of life of human beings, and it has become a disease that seriously jeopardizes the life and health of human beings, but the pathogenesis of the disease is still not clear. As a member of the CC chemokine family, monocyte chemotactic protein 1 (MCP-1) is involved in the development of a variety of autoimmune diseases, and the results of current studies have shown that MCP-1 is associated with macrovascular and microvascular lesions and neurological complications of T2DM, and may be involved in its pathogenesis. In this article, we discuss the research progress of MCP-1 in type 2 diabetes mellitus and its complications. |
View Fulltext
查看/发表评论 下载PDF阅读器 |
|
|
|