文章摘要
苏春龙,王凤鸽,朱梁喜,张凡勇.妊娠中期孕妇血清游离β-人绒毛膜促性腺激素与前置胎盘合并胎盘植入的关联性[J].济宁医学院学报,2022,45(6):414-417,423
妊娠中期孕妇血清游离β-人绒毛膜促性腺激素与前置胎盘合并胎盘植入的关联性
Study on the relationship between serum free β-humanchorionic gonadotropin and placenta previa withplacenta accreta in the second trimester of pregnancy
投稿时间:2022-03-09  
DOI:10.3969/j.issn.1000-9760.2022.06.007
中文关键词: 妊娠;胎盘;胎盘植入;母体血清标志物;游离β-人绒毛膜促性腺激素
英文关键词: Pregnancy;Placenta;Placenta accreta;Maternal serum marker;Free-β-HCG
基金项目:国家自然科学基金(82201876);济宁市重点研发项目(2019SMNS015)
作者单位E-mail
苏春龙 济宁医学院临床医学院, 济宁 272013  
王凤鸽 济宁医学院附属医院, 济宁 272029  
朱梁喜 济宁医学院附属医院, 济宁 272029  
张凡勇 济宁医学院附属医院, 济宁 272029 zhangfanyongjn@163.com 
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中文摘要:
      目的 探讨妊娠中期游离β-人绒毛膜促性腺激素(free-β-HCG)与胎盘植入之间的关系。方法 选自2016年4月至2020年7月于济宁医学院附属医院终止妊娠的孕妇504例,其中前置胎盘合并胎盘植入者即为胎盘植入组105例,单纯前置胎盘者为前置胎盘组122例,健康孕妇277例即对照组。回顾性分析其临床资料,收集血清筛查中free-β-HCG值,并进行统计学分析。结果 胎盘植入组free-β-HCG水平高于前置胎盘组和对照组(P<0.001)。在调整取样时的孕周、体重指数和年龄后,血清free-β-HCG与胎盘植入有关联性(P<0.001)。结论 妊娠中期血清free-β-HCG水平升高与胎盘植入存在关联性,提示free-β-HCG可能在预测前置胎盘合并胎盘植入中发挥作用。
英文摘要:
      Objective To investigate the relationship between Free-β-HCG and placenta accreta in the second trimester of pregnancy.Methods A total of 504 pregnant women from April 2016 to July 2020 were enrolled in this study (105 patients with placenta accreta,122 patients with non-adherent placenta previa,and 277 healthy pregnant controls)。 Their clinical data were analyzed retrospectively,and the free-β-HCG values of serological screening in second-trimester pregnancy were collected and statistically analyzed.Results There was no statistical significance in maternal age,BMI,reproductive history,abortion history,cesarean section history,gestational age of blood collection and HCG value.The serum free-β-HCGlevel of the placentaaccreta group is higher than that of the placenta previa and the control group(P<0.001).Serum free-β-HCG was correlated with placenta accreta after adjusting for gestational week at the time of blood sampling,body mass index,and age(P<0.001).RConclusion Increased level of second trimester serum free-β-HCG was associated with placenta accreta,whichindicatesthe possible role of free-β-HCG in the prediction of placenta previa complicated with placental accreta.
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