.HuR与非小细胞肺癌[J].济宁医学院学报,2022,45(2):123-126 |
HuR与非小细胞肺癌 |
HuR in non-small cell lung cancer |
投稿时间:2021-09-16 |
DOI:10.3969/j.issn.1000-9760.2022.02.012 |
中文关键词: HuR;RNA结合蛋白;非小细胞肺癌;靶向治疗 |
英文关键词: HuR;RNA-binding proteins;Non-small cell lung cancer;Targeted therapy |
基金项目:济宁医学院贺林院士新医学临床转化工作站科研基金(JYHL2018FMS14) |
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1.济宁医学院临床医学院,济宁 272013;2.济宁医学院附属医院,济宁 272029 |
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中文摘要: |
非小细胞肺癌(non-small cell lung cancer, NSCLC)是最常见的肺癌病理类型,由于早期临床症状不典型,多数患者确诊时已为中晚期。人类抗原R(Hu-antigen R,HuR)是目前研究最广泛的一种RNA结合蛋白(RNA binding proteins,RBPs),在多种肿瘤的胞浆中高表达,并参与调节肿瘤相关基因转录后表达。本文就HuR在非小细胞肺癌中的相关研究进展做一综述。 |
英文摘要: |
Non-small cell lung cancer(NSCLC)is the most common pathological type of lung cancer.As there are not typical clinical symptoms in the early stage, it is already in the middle oradvanced stage when diagnosed.Hu-antigen R(HuR)is one of the most widely studied RNA binding proteins(RBPs)with highly cytoplasmic expression, participating in the regulation of post-transcriptional expression of tumor-related genes.This paper will review the research progress of HuR in non-small cell lung cancer. |
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