| 朱钰,李永华.线粒体自噬受体FUNDC1研究进展[J].济宁医学院学报,2021,44(6):442-446 |
| 线粒体自噬受体FUNDC1研究进展 |
| Advances in the study of mitochondrial autophagy receptor containing FUN14 domain protein |
| 投稿时间：2021-09-18 |
| DOI：10.3969/j.issn.1000-9760.2021.06.015 |
| 中文关键词: 线粒体;线粒体自噬;FUNDC1 |
| 英文关键词: Mitochondria;Mitochondrial autophagy;FUNDC1 |
| 基金项目: |
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| 中文摘要: |
| 线粒体是细胞内能量代谢的主要场所,线粒体自噬是通过选择性清除受损和功能障碍的线粒体来阻止过量活性氧簇(reactive oxygen species,ROS)的产生,从而防止细胞死亡的过程,是维持线粒体稳态的关键。FUNDC1 是一种新型线粒体自噬受体蛋白,在介导线粒体自噬方面发挥重要调节作用。本文主要就近年来线粒体自噬中FUNDC1调控机制及其病理生理意义的研究进展做一综述。 |
| 英文摘要: |
| Mitochondria are the main sites of energy metabolism in cells.Mitochondrial autophagy prevents the production of excessive ROS by selectively clearing damaged and dysfunctional mitochondria,thus preventing cell death,which is the key to maintaining mitochondrial homeostasis.FUNDC1 is a novel mitochondrial autophagy receptor protein,which plays an important regulatory role in mediating mitochondrial autophagy.This article mainly reviews the recent research progress on the mechanism of FUNDC1 regulation in mitochondrial autophagy and its pathophysiological significance. |
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