文章摘要
李青文,李传方,曹勇,甘立军.急性心肌梗死患者空腹血糖水平与左室射血分数的关联性[J].济宁医学院学报,2021,44(4):252-256
急性心肌梗死患者空腹血糖水平与左室射血分数的关联性
Correlation study between fasting plasma glucose level and left ventricular ejection fraction in patients with acute myocardial infarction
投稿时间:2021-06-04  
DOI:10.3969/j.issn.1000-9760.2021.04.006
中文关键词: 急性心肌梗死;空腹血糖;左室射血分数
英文关键词: AMI;FPG;LVEF
基金项目:济宁市重点研发计划项目(2020JKNS006)
作者单位E-mail
李青文 济宁医学院临床医学院, 济宁 272013  
李传方 济宁医学院附属医院
济宁市心血管疾病诊疗重点实验室, 济宁 272029 
 
曹勇 济宁医学院附属医院
济宁市心血管疾病诊疗重点实验室, 济宁 272029 
 
甘立军 济宁医学院附属医院
济宁市心血管疾病诊疗重点实验室, 济宁 272029 
13792336453@163.com 
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中文摘要:
      目的 探讨急性心肌梗死(acute myocardial infarction,AMI)患者空腹血糖水平(fasting plasma glucose,FPG)与左室射血分数(left ventricular ejection fraction,LVEF)的关联性。方法 选取2019年8月1日至2021年3月31日于济宁医学院附属医院经急诊绿色通道行经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗并于心脏急诊科住院的421名AMI患者为研究对象,收集患者基本信息、既往病史、实验室检查、心脏超声检查以及冠脉造影结果等临床资料,分析FPG水平和LVEF<50%发生风险的关联性。结果 与LVEF≥50%患者相比,LVEF<50%患者的FPG显著升高。单因素分析显示FPG与LVEF<50%的发生存在关联关系(P<0.05)。校正了混杂因素以后,通过平滑曲线拟合发现FPG与LVEF<50%呈线性关系。多个回归方程模块分析结果提示两者线性关系稳定,调整混杂因素后可发现,FPG每增加1 mmol/L,LVEF<50%的发生风险增加12%(OR=1.12,P=0.008)。将FPG分为FPG<6.1mmol/L、FPG 6.1~6.9mmol/L以及FPG≥7.0mmol/L 3组,分层分析显示,不同状态下FPG水平升高均可增加LVEF<50%发生风险。结论 AMI患者FPG水平升高可增加LVEF<50%的发生风险。
英文摘要:
      Objective To explore the relationship between fasting plasma glucose (FPG) and left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI).Methods 421 AMI patients were selected who underwent percutaneous coronary intervention (PCI) in the Affiliated Hospital of Jining Medical University via the emergency green channel from August 1, 2019 to March 31, 2021 and were hospitalized in the cardiac emergency department as the study subjects.Clinical data were collected including basic information, past medical history, laboratory examination, ultrasonic cardiogram and coronary angiography results of patients to analyze the correlation between FPG level and the risk of LVEF<50%.Results Patients with LVEF<50% had significantly higher FPG levels than those with LVEF ≥ 50%.Univariate analysis showed that FPG was associated with the occurrence of LVEF<50%(P<0.05).After adjusting confounding factors, it was found that FPG and LVEF<50% had a linear relationship through smooth curve fitting.Analysis result of multiple regression equation modules indicated that the linear relationship between the two was stable.After adjusting confounding factors, it could be found that for every 1 mmol/L increase in FPG, the risk of LVEF<50% increased by 12%(OR=1.12, P=0.008).Divide FPG into 3 groups:FPG<6.1mmol/L, FPG 6.1~6.9mmol/L and FPG ≥ 7.0mmol/L, after adjusting confounding factors, stratified analysis showed that the increase of FPG under different glucose metabolism states was related to the increased risk of LVEF<50% and had different effects on LVEF.Conclusion There is a linear positive correlation between the FPG level of AMI patients and the risk of LVEF<50%.As the FPG level increases, the risk of LVEF<50% increases, and the FPG level under different glucose metabolism states has different effects on LVEF.
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