文章摘要
李金辉,孙春山,刘磊.MIR4435-2HG、miR-128-3p在膀胱尿路上皮癌中的表达及其相关性[J].济宁医学院学报,2021,44(4):246-251
MIR4435-2HG、miR-128-3p在膀胱尿路上皮癌中的表达及其相关性
The expression significance and correlation of MIR4435-2HG and miR-128-3p in urothelial carcinoma of the bladder
投稿时间:2021-01-20  
DOI:10.3969/j.issn.1000-9760.2021.04.005
中文关键词: 膀胱尿路上皮癌;MIR4435-2HG;微小RNA-128-3p;预后;相关性
英文关键词: Bladder urothelial carcinoma;MIR4435-2HG;MicroRNA-128-3p;Prognosis;Correlation
基金项目:
作者单位E-mail
李金辉 郑州人民医院, 郑州 450000  
孙春山 郑州人民医院, 郑州 450000  
刘磊 郑州人民医院, 郑州 450000 Liulei_pwk@163.com 
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中文摘要:
      目的 探讨长链非编码RNA MIR4435-2HG与miR-128-3p在膀胱尿路上皮癌中的表达意义及相关性。方法 采用实时荧光定量PCR检测87例膀胱尿路上皮癌组织及癌旁正常组织MIR4435-2HG和miR-128-3p的表达,将患者分别分为MIR4435-2HG高表达组(44例)、MIR4435-2HG低表达组(43例)或miR-128-3p高表达组(39例)、miR-128-3p低表达组(48例);比较两组间病理资料和预后生存差异;分析MIR4435-2HG和miR-128-3p表达的相关性。结果 膀胱尿路上皮癌组织中MIR4435-2HG表达水平明显高于癌旁组织,而miR-128-3p表达水平明显低于癌旁组织(P<0.05),且MIR4435-2HG和miR-128-3p表达呈负相关(r=-0.544,P<0.05)。MIR4435-2HG低表达和高表达组在病理分级、临床分期和淋巴结转移方面有统计学差异(P<0.05),而miR-128-3p低表达和高表达组各资料均无统计学差异(P>0.05);MIR4435-2HG高表达患者生存率低于MIR4435-2HG低表达组,而miR-128-3p高表达患者总生存率高于miR-128-3p低表达组(P<0.05)。MIR4435-2HG高表达和miR-128-3p低表达是影响膀胱尿路上皮癌患者预后的独立危险因素。结论 膀胱尿路上皮癌组织MIR4435-2HG表达上调,miR-128-3p表达下调,两者均是患者预后不良的危险因素。
英文摘要:
      Objective To investigate the expression significance and correlation of long non-coding RNA MIR4435-2Hg and miR-128-3p in urothelial carcinoma.Methods The expressions of MIR4435-2HG and miR-128-3p in 87 cases of bladder urothelial carcinoma tissue and adjacent normal tissues were detected by real-time quantitative PCR.The patients were divided into high MIR4435-2HG group (44 cases) and low MIR4435-2HG group (43 cases), high miR-128-3p group (39 cases) and low miR-128-3p group (48 cases);the difference of pathological data and prognosis between the two groups was compared, and the correlation between the expression of MIR4435-2HG and miR-128-3p was analyzed.Results The expression level of MIR4435-2HG in bladder urothelial carcinoma tissue was significantly higher than that in adjacent tissues, while the expression level of miR-128-3p was significantly lower than that in adjacent tissues (P<0.05), and the expression level of MIR4435-2HG and miR-128-3p was negatively correlated (r=-0.544, P<0.05).There were statistical differences in pathological grade, clinical stage and lymph node metastasis between the low and high MIR4435-2HG group (P<0.05), while there were no statistical differences in all data between the low and high miR-128-3p group(P<0.05);The survival rate of patients with high MIR4435-2HG was lower than that of low MIR4435-2HG group, while the overall survival rate of patients with high miR-128-3p was higher than that with low miR-128-3p group (P<0.05).High MIR4435-2HG and low miR-128-3p were independent risk factors for prognosis in patients with bladder urothelial carcinoma.Conclusion The expression of MIR4435-2HG in bladder urothelial carcinoma tissue was up-regulated, and the expression of miR-128-3p was down-regulated, both of which were risk factors for poor prognosis.
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