文章摘要
林光耀,张米佳,叶涛,王永周.腹腔镜联合术前使用亮丙瑞林治疗子宫内膜异位症的Meta分析[J].济宁医学院学报,2021,44(2):128-134
腹腔镜联合术前使用亮丙瑞林治疗子宫内膜异位症的Meta分析
The combined use of leuprorelin in the treatment of endometriosis before laparoscope:meta-analysis and literature review
投稿时间:2020-12-24  
DOI:10.3969/j.issn.1000-9760.2021.02.013
中文关键词: 腹腔镜;亮丙瑞林;子宫内膜异位症;Meta分析
英文关键词: Laparoscope;Leuprorelin;Endometriosis;Meta-analysis
基金项目:四川省中医药管理局项目(2018YY010);西南医科大学-西南医科大学附属中医医院联合项目(2020XYLH-042)
作者单位E-mail
林光耀 西南医科大学附属中医医院, 泸州 646000  
张米佳 西南医科大学附属中医医院, 泸州 646000  
叶涛 西南医科大学附属中医医院, 泸州 646000  
王永周 西南医科大学附属中医医院, 泸州 646000 fkwyz123747@163.com 
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中文摘要:
      目的 系统评价腹腔镜联合术前使用亮丙瑞林治疗子宫内膜异位症的临床有效性。方法 通过计算机检索PubMed、EBSCO、中国万方、知网以及维普数据库,收集其从建库起至2020年4月间所有关于腹腔镜联合术前使用亮丙瑞林治疗子宫内膜异位症的临床随机对照试验。依据本研究的纳入及排除标准,由2位研究者总计筛选出文献449篇,最终纳入15篇文献,总病例数为1465例,其中试验组746例,对照组719例,使用Rev Man5.3软件进行研究分析。结果 腹腔镜联合术前使用亮丙瑞林治疗子宫内膜异位症较单纯使用腹腔镜治疗可显著降低患者血清卵泡刺激素水平(MD=-1.49,95%CI[-2.03,-0.95],P<0.001),同时患者妊娠率提高18%(RD=0.18,95%CI[0.11,0.25],P<0.001),复发率降低17%(RD=-0.17,95%CI[-0.22,-0.12],P<0.001),且能增加窦卵泡数(MD=0.84,95%CI[0.73,0.95],P<0.001)。结论 应用腹腔镜治疗子宫内膜异位症患者时,于术前给予亮丙瑞林治疗,在改善患者的血清激素水平,提高妊娠率,增加窦卵泡数以及降低复发率优于单用腹腔镜治疗。
英文摘要:
      Objective To systematically evaluate the clinical efficacy of Leuprorelin in the treatment of endometriosis before laparoscope.Methods The databases of PubMed、EBSCO、Wanfang、CNKI and VIP were searched,and collected the randomized controlled trials of clinical data about the use of Leuprorelin in the treatment of endometriosis before laparoscope from the establishment of the database to April 2020.According to the inclusion and exclusion criteria of this study,a total of 449 articles were screened out by two researchers,and finally 15 articles were included.The total cases were 1465,including 746 cases in the experimental group and 719 cases in the control group.Rev Man5.3 software was used for analysis.Results By Comparing with operating laparoscope alone,the combined use of Leuprorelin to treat endometriosis before laparoscope could significantly reduce follicle stimulating hormone(MD=-1.49,95%CI[-2.03,-0.95],P<0.001),increase the pregnancy rate of patients by 18%(RD=0.18,95%CI[0.11,0.25],P<0.001)and decrease the recurrence rate by 17%(RD=-0.17,95%CI[-0.22,-0.12],P<0.001).Meanwhile,it increased the number of antral follicles count (MD=0.84,95%CI[0.73,0.95],P<0.001).Conclusion Before operating laparoscope to treat endometriosis,combining use of Leuprorelin is better than the treatment of laparoscope alone.It not only improves patients' serum hormone level,increases pregnancy rate and the number of antral follicles count but also reduce the recurrence rate.
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