齐硕,毕研蒙.肠道菌群与肝纤维化的相关性[J].济宁医学院学报,2021,44(1):5-9 |
肠道菌群与肝纤维化的相关性 |
The relationship between intestinal flora and hepatic fibrosis |
投稿时间:2020-08-31 |
DOI:10.3969/j.issn.1000-9760.2021.01.002 |
中文关键词: 肠道菌群;微生态平衡;肝纤维化;“肠-肝轴”;Toll样受体 |
英文关键词: Intestinal flora;Microecological balance;Hepatic fibrosis;“Intestine-liver axis”;Toll-like receptors |
基金项目:山东省中医药科技发展计划项目(2019-0447);济宁医学院中西医结合治疗脾胃病重点学科项目(济医院字[2019]18号) |
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中文摘要: |
目前,肠道微生态已成为当今研究热点之一,肠道菌群的变化对机体生理功能的影响至关重要。肝纤维化是各种慢性肝病向肝纤维化发展过程中的关键步骤和影响慢性肝病预后的重要环节。肠道菌群的微生态平衡与失调影响肝纤维化过程的发展。同样,在肝纤维化发展过程中,肠道菌群也发生不同程度的改变。本文主要介绍肠道微生态平衡与失衡、肠道菌群参与肝纤维化的过程、“肠-肝轴”与肝纤维化的关系。 |
英文摘要: |
In recent years,intestinal microecology has become one of the current research hotspots,and the change of intestinal flora has an important influence on the physiological functions of the body.Hepatic fibrosis is a key step in the development of various chronic liver diseases to liver fibrosis and an important link that affects the prognosis of chronic liver diseases.The imbalance of the microecological balance of the intestinal flora will affect the development of liver fibrosis.Similarly,the pathological process of hepatic fibrosis can lead to varying degrees of changes in the intestinal flora.This article mainly summarizes the intestinal microecological balance and imbalance,the involvement of intestinal flora in the process of liver fibrosis,the relationship between "gut-liver axis" and liver fibrosis. |
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