| 徐思博,刘晓静.高尿酸血症与非酒精性脂肪肝的关系研究进展[J].济宁医学院学报,2020,43(1):59-62,67 |
| 高尿酸血症与非酒精性脂肪肝的关系研究进展 |
| Study progress on the relationship between hyperuricemia and nonalcoholic fatty liver disease |
| 投稿时间：2020-01-14 |
| DOI：10.3969/j.issn.1000-9760.2020.01.014 |
| 中文关键词: 高尿酸血症;非酒精性脂肪肝;氧化应激 |
| 英文关键词: Hyeruricemia;Nonalcoholic fatty liver disease;Oxidative stress |
| 基金项目:青岛大学附属医院2018年博士科研启动基金（No：3274）；青岛大学附属医院青年科研基金（No：3086） |
| 作者 | 单位 | E-mail | | 徐思博 | 青岛大学附属医院, 青岛 266000
青岛大学医学部临床医学院, 青岛 266071 | | | 刘晓静 | 青岛大学附属医院, 青岛 266000 | liuxiaojing@126.com |
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| 中文摘要: |
| 高尿酸血症（hyperuricemia，HUA）是由于人体内嘌呤代谢紊乱所导致。非酒精性脂肪性肝病（nonalcoholic fatty liver disease，NAFLD）是临床最常见的慢性肝病之一，并且患病率呈现不断上升趋势。流行病学研究显示，HUA人群中NAFLD的患病率增高，病变程度加重，HUA是发生NAFLD的独立影响因素之一。两者相互作用机制可能与HUA导致的肝细胞脂质代谢紊乱、氧化应激损伤和胰岛素敏感性下降有关。目前尚无HUA直接诱导NAFLD的动物实验模型或高尿酸加重NAFLD的动物模型，两者相互作用的具体机制仍不明确，有待进一步研究。 |
| 英文摘要: |
| Hyperuricemia is caused by disorder of purine metabolism.NAFLD is one of the most common chronic liver diseases,and the prevalence is on the rise.Epidemiological studies indicated that the prevalence of NAFLD in HUA population was increased and the lesion degree was aggravated.HUA was also an independent influencing factor for the occurrence of NAFLD.It was found that the interaction mechanism may be related to lipid metabolism disorder,oxidative stress injury and decreased insulin sensitivity of liver cells caused by HUA.At present,there is no animal experimental model in which HUA directly induces NAFLD or in which increased uric acid aggravates NAFLD.The specific mechanism of the interaction between the two is still unclear and needs to be studied. |
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