刘利娟,李傲.SphK1/S1P信号通路在肺纤维化发生中的作用[J].济宁医学院学报,2019,42(6):424-427 |
SphK1/S1P信号通路在肺纤维化发生中的作用 |
The role of SphK1/S1P signaling pathway in pulmonary fibrosis |
投稿时间:2019-06-10 |
DOI:10.3969/j.issn.1000-9760.2019.06.011 |
中文关键词: 1-磷酸鞘氨醇;1-磷酸鞘氨醇受体;鞘氨醇激酶;肺纤维化 |
英文关键词: Sphingosine 1-phosphate;Sphingosine 1-phosphate receptors;Sphingosine kinases;Pulmonary fibrosis |
基金项目:国家自然科学基金(81703687);重庆市卫生和计划生育委员会中医药科技项目(ZY201702122);重庆理工大学研究生创新项目(ycx2018250) |
作者 | 单位 | E-mail | 刘利娟 | 重庆理工大学药学与生物工程学院, 重庆 400054 | | 李傲 | 重庆理工大学药学与生物工程学院, 重庆 400054 | ao_li@cqut.edu.cn |
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中文摘要: |
纤维化是一种病理过程,其以细胞外基质(extracellular matrix,ECM)的大量沉积为主要特征。纤维化发生在包括肺、肝脏、心脏和肾脏在内的各种器官中,最终导致器官结构扭曲和严重功能障碍。1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)是一种具有生物活性的溶血磷脂,发挥多种活性,包括细胞增殖、存活、分化、迁移、炎症、血管生成和内皮屏障完整性等过程。越来越多的证据表明,SphK1/S1P信号通路在肺纤维化疾病的发生发展中起着重要作用,研究其相关作用与功能,可为治疗难治性纤维化性疾病提供新的思路和药物治疗靶点。 |
英文摘要: |
Fibrosis is a pathological process characterized by massive deposition of extracellular matrix (ECM).Fibrosis occurs in various organs including the lung,liver,heart,and kidney,eventually leading to structural distortion and severe dysfunction.Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid that exerts a variety of activities including cell proliferation,survival,differentiation,migration,inflammation,angiogenesis,and endothelial barrier integrity.Many studies suggests that SphK1/S1P signaling pathway plays an important role in the occurrence and development of pulmonary fibrosis.The functional mechanisms of S1P would provide potential therapeutic strategies and targets for refractory fibrotic diseases. |
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