| 陈岳彤,武菲.蛋白激酶CK2神经生物学特性及功能研究进展[J].济宁医学院学报,2019,42(4):279-284 |
| 蛋白激酶CK2神经生物学特性及功能研究进展 |
| Advances in neurobiological characteristics and function of protein kinase CK2 |
| 投稿时间：2019-01-03 |
| DOI：10.3969/j.issn.1000-9760.2019.04.012 |
| 中文关键词: 酪蛋白激酶;CK2;神经元;突触传递;神经保护 |
| 英文关键词: Casein kinase;CK2;Neuron;Synaptic transmission;Neuroprotection |
| 基金项目:山东省自然科学基金（ZR2019PC007）；济宁医学院青年教师科研扶持基金（JYFC2018KJ022）；济宁医学院大学生创新训练计划项目（cx2018031） |
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| 摘要点击次数: 2072 |
| 全文下载次数: 1955 |
| 中文摘要: |
| 蛋白激酶CK2是一种普遍存在的多效性丝/苏氨酸蛋白激酶，在非神经细胞中发挥重要作用。近年来研究证实CK2在神经系统中也扮演不可或缺的角色：CK2在大脑中大量表达，底物众多，通过磷酸化底物参与多种信号通路；在神经元中，CK2存在于突触和细胞核等多种基质，并证实其参与调制神经元发育与生长、突触形成、突触传递、突触的可塑性、学习与记忆等生理活动；一些神经因子或化合物可通过CK2起着神经营养或保护作用。本文将对CK2的生物学特性及神经生物学功能研究的最新进展作一综述。 |
| 英文摘要: |
| Protein kinase CK2 is a kind of ubiquitous multipotent serine/threonine protein kinase,which plays an important role in non-nervous cells.Recent studies have confirmed that CK2 also shows indispensable effects in the nervous system:(1) CK2 is abundantly expressed in brain and modulates plentiful substrates via phosphorylation participating in many signaling pathways; (2) CK2 exists in synapses,nuclei and other substrates in neurons,and has been proved to be involved in neuronal physiological activities such as development and growth,synaptogenesis and synaptic transmission,synaptic plasticity,learning and memory; (3) some neurokines or compounds could play neurotrophic or neuroprotective roles through CK2.This review will focus on the latest advances in the biological characteristics and neurobiological functions of CK2. |
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