崔平,翟敏,孙莉,刘苗苗,张妍,郭立燕.MDM2基因多态性与食管癌胃癌易感性的关系Meta分析[J].济宁医学院学报,2019,42(2):88-94 |
MDM2基因多态性与食管癌胃癌易感性的关系Meta分析 |
Association between MDM2 gene polymorphism and susceptibility of esophageal carcinoma and gastric carcinoma: a Meta-analysis |
投稿时间:2019-01-20 |
DOI:10.3969/j.issn.1000-9760.2019.02.004 |
中文关键词: MDM2;食管癌;胃癌;病例对照研究;Meta分析 |
英文关键词: MDM2 oncogene;Esophageal Carcinoma;Gastric Carcinoma;Case-control Study;Meta-analysis |
基金项目:山东省医药卫生科技计划项目(2011HZ015);济宁医学院科研计划重点项目(JY2013KJ001) |
作者 | 单位 | E-mail | 崔平 | 济宁医学院公共卫生学院, 济宁 272013 | | 翟敏 | 济宁医学院公共卫生学院, 济宁 272013 | | 孙莉 | 济宁医学院公共卫生学院, 济宁 272013 | | 刘苗苗 | 济宁医学院公共卫生学院, 济宁 272013 | | 张妍 | 济宁医学院公共卫生学院, 济宁 272013 | | 郭立燕 | 济宁医学院公共卫生学院, 济宁 272013 | yz220@126.com |
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中文摘要: |
目的 探求鼠双微体基因2(Murine Doubleminute 2,MDM2)基因多态性与食管癌、胃癌易感性的关系。方法 运用计算机检索PubMed、Embase、中国知网、万方、维普数据库,收集有关MDM2多态性与食管癌、胃癌易感性的病例对照研究文献,纳入符合标准的文献,提取数据进行Meta分析。结果 共有16篇文献符合条件并纳入研究。Meta分析结果表明:显性基因型(TT+TG)的个体对食管癌/胃癌的易感性降低,TT+TG vs GG:OR=0.73,95% CI=(0.59,0.91),P<0.001。与变异纯合子(GG)基因型相比,野生纯合子(TT)基因型的个体中患食管癌、胃癌的风险降低,TT vs GG:食管癌易感性OR=0.79,95% CI=(0.68,0.93),P=0.005,胃癌易感性OR=0.52,95% CI=(0.38,0.72),P<0.001;变异杂合子(TG)基因型的个体中患胃癌的风险降低,TG vs GG:食管癌易感性OR=0.74,95% CI=(0.48,1.14),P=0.173、胃癌易感性OR=0.62,95% CI=(0.50,0.75),P<0.001;而野生纯合子(TT)基因型与变异杂合子(TG)基因型相比,个体患食管癌、胃癌的风险差别无统计学意义,TT vs TG:食管癌易感性OR=1.01,95% CI=(0.80,1.27),P=0.966、胃癌易感性OR=0.85,95% CI=(0.67,1.08),P=0.193。结论 MDM2基因多态性与食管癌、胃癌易感性相关,MDM2显性基因型(TT、TG)与食管癌、胃癌患病易感性的降低有关。 |
英文摘要: |
Objective To investigate the association between MDM2 polymorphism and susceptibility of esophageal carcinoma and gastric carcinoma.Methods We used PubMed, Embase, CNKI, Wanfang and the VIP database to search the articles which focused on the association between MDM2 polymorphism and esophageal squamous cell carcinoma or gastric carcinoma.The study design of the article was case-control study.Pooled results were showed by the odds ratio (OR) and 95% confidence interval (CI).Results Meta-analysis showed that Dominant genotype (TT,TG) of MDM2 could reduce the risk of the esophageal squamous cell carcinoma or gastric cancer,TT+TG vs.GG:OR=0.73,95% CI=(0.59,0.91),P<0.001.Compared with mutant homozygote (GG), wild homozygote (TT) could reduce the risk of the esophageal squamous cell carcinoma and gastric cancer, TT vs.GG:esophageal squamous cell carcinoma OR=0.79,95% CI=(0.68, 0.93),P=0.005;gastric cancer OR=0.52,95% CI=(0.38,0.72),P<0.001;mutant heterozygote(TG) could only reduce the risk of the gastric cancer,TG vs.GG:esophageal squamous cell carcinoma OR=0.74,95% CI=(0.48,1.14),P=0.173;gastric cancer OR=0.62,95% CI=(0.50,0.75),P<0.001.However, there was no statistical significance in TT vs TG:esophageal squamous cell carcinoma OR=1.01,95% CI=(0.80, 1.27),P=0.966;gastric cancer OR=0.85,95% CI=(0.67,1.08),P=0.193.Conclusion The MDM2 genic polymorphism may be impact the risk of esophageal squamous cell carcinoma and gastric cancer.Dominant genes (TT, TG) could reduce the risk of the esophageal squamous cell carcinoma and gastric cancer. |
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