| 代丽丽,张国安,崔文.BRAFV600E和TERT启动子突变与甲状腺乳头状癌的关系[J].济宁医学院学报,2018,41(4):290-293 |
| BRAFV600E和TERT启动子突变与甲状腺乳头状癌的关系 |
| The correlation between BRAFV600E mutation and TERT promoter mutation with papillary thyroid carcinoma |
| 投稿时间：2017-06-12 |
| DOI：10.3969/j.issn.1000-9760.2018.04.016 |
| 中文关键词: 甲状腺乳头状癌;BRAFV600E突变;TERT启动子突变 |
| 英文关键词: Thyroid papillary carcinoma;BRAFV600Emutation;TERT promoter mutation |
| 基金项目:山东省高等学校科技计划（J13 LK14） |
| 作者 | 单位 | E-mail | | 代丽丽 | 济南大学山东省医学科学院与生命科学学院, 济南 250022 | | | 张国安 | 济宁医学院司法鉴定中心 | | | 崔文 | 济宁医学院, 济宁 272067 | cuiwenmd@163.com |
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| 中文摘要: |
| 近几年甲状腺癌的发病率呈逐渐上升趋势，是内分泌系统最常见的恶性肿瘤。甲状腺癌根据组织学特点分为4种病理类型，乳头状癌是其最常见的病理类型。在甲状腺乳头状癌的发生和发展中有多种基因参与，其中TERT启动子突变和BRAFV600E基因突变在甲状腺乳头状癌的发生与发展中发挥着重要作用，并且可能与患者临床病理学特征和不良预后具有相关性。因此，正确全面了解TERT和BRAFV600E基因在甲状腺乳头状癌中的突变特点以及相互作用有助于为甲状腺乳头状癌患者的预后判断和个体化诊治提供依据，从而为靶基因治疗奠定基础。 |
| 英文摘要: |
| Thyroid carcinoma (TC) is the most common malignant tumor of the endocrine system which is rising rapidly in recent years.TC is divided into four pathological types,of which papillary carcinoma is the most common pathological type.There are numbers of genes involved in the occurrence and development of thyroid papillary carcinoma.Recently,some researchs find that the mutation of TERT promoter and BRAFV600E in thyroid papillary carcinoma plays an important role,which may be associated with clinical pathologic features and poor prognosis.Therefore,comprehensive understanding the mutation characteristics and interaction of TERT promoter and BRAFV600E gene in the thyroid papillary carcinoma helps to provide the basis for the judge prognosis and individualized treatment and lay the foundation for target gene therapy of papillary thyroid carcinoma. |
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