姜云璐,王正文,陈京,白波.胆囊收缩素Ⅱ型受体研究进展[J].济宁医学院学报,2018,41(3):199-203 |
胆囊收缩素Ⅱ型受体研究进展 |
Research progress of cholecystokinin type Ⅱ receptor |
投稿时间:2017-06-06 |
DOI:10.3969/j.issn.1000-9760.2018.03.012 |
中文关键词: 胆囊收缩素Ⅱ型受体;恐慌;焦虑;镇痛;癌症 |
英文关键词: Cholecystokinin type Ⅱ receptor;panic;anxiety;analgesia;cancer |
基金项目:国家自然科学基金(3097108;816712276;31271243;81070961);山东省自然科学基金(ZR2018PC011);济宁医学院教师科研扶持基金(JY2017KJ035);山东省高校科技计划项目(2015-57-6;JY2015KJ004) |
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中文摘要: |
胆囊收缩素受体属于G蛋白偶联受体,具有两种亚型,广泛分布于神经系统和消化系统。胆囊收缩素Ⅱ型受体不仅参与神经内分泌类肿瘤、胰腺癌、胃癌、结肠癌的发生发展,在恐慌、镇痛、学习记忆及焦虑等也发挥重要的调节作用。本文就胆囊收缩素Ⅱ型受体研究进展作一综述。 |
英文摘要: |
Cholecystokinin receptor widely distributed in the nervous system and digestive system belongs to the G protein coupled receptor,which has two subtypes.The researches show that cholecystokinin type Ⅱ receptor not only is involved in the development of neuroendocrine tumors,pancreatic cancer,gastric cancer and colon cancer,but also plays an important role in panic,analgesia,learning and memory and anxiety.In this paper,we review the research progress on the function of cholecystokinin type Ⅱ receptor. |
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