王姗,范修德,尹盼盼,王小云,许君望.基于数据挖掘分析HMGB1表达对胃癌预后的影响[J].济宁医学院学报,2018,41(1):64-68 |
基于数据挖掘分析HMGB1表达对胃癌预后的影响 |
The expression and prognostic significance of HMGB1 in gastric carcinoma utilizing Oncomine datasets |
投稿时间:2017-10-09 |
DOI:10.3969/j.issn.1000-9760.2018.01.016 |
中文关键词: 胃癌;HMGB1;Oncomine;数据库 |
英文关键词: Gastric cancer;HMGB1;Oncomine database |
基金项目: |
作者 | 单位 | E-mail | 王姗 | 西安交通大学第一附属医院, 西安 710061 西安航天总医院, 西安 710100 | | 范修德 | 西安交通大学第一附属医院, 西安 710061 | | 尹盼盼 | 济宁医学院附属医院, 济宁 272029 | | 王小云 | 西安交通大学第一附属医院, 西安 710061 | | 许君望 | 西安交通大学第一附属医院, 西安 710061 | xujwdoctor@aliyun.com |
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中文摘要: |
目的 本文基于数据挖掘探索高迁移率族蛋白1(HMGB1)在胃癌中的表达及对预后的影响。方法 Oncomine数据库提取 HMGB1 在胃癌组织和正常组织中转录水平的变化数据,并对数据库中的基因表达信息进行二次分析;利用Kaplan-Meier Plotter分析HMGB1表达水平与胃癌预后的关系。结果 Oncomine数据库中共收集了443项不同类型的研究结果,其中关于HMGB1表达有统计学差异的研究结果有20项,HMGB1表达增高的研究有17项、表达降低的研究有3项,在胃癌中高表达的研究有1项,低表达的有0项。11项研究涉及HMGB1在胃癌组织和正常组织中的转录水平的表达,共包括318个样本,与正常组织相比,HMGB1在胃癌组织中高表达(P=0.002)。不仅如此,Kaplan-Meier Plotter数据库分析结果显示,HMGB1的mRNA表达量与胃癌总体生存率存在相关性,即高表达HMGB1的患者总体生存率较好,低表达HMGB1的患者预后较差(P=1.8E-05)。结论 HMGB1 mRNA在胃癌组织中高表达,而且与肠型胃癌预后相关,这为探索HMGB1在胃癌中的作用提供了基础,也为今后胃癌的临床治疗和预后研究提供重要理论依据。 |
英文摘要: |
Objective To investigate the expression and prognostic significance of HMGB1 mRNA in gastric carcinoma utilizing Oncomine datasets.Methods The data about the expression of HMGB1 in gastric carcinoma and normal tissues were extracted from Oncomine.The prognostic roles of HMGB1 in gastric cancer patients were analyzed by using Kaplan-Meier Plotter.Results In Oncomine database,there were 443 studies of different types concerning expression of HMGB1,of which 20 studies were of statistically significance (17 up-regulated and 3 down-regulated).In gastric carcinoma1were up-regulated and 0 were down-regulated.A total of 11 studies were involved HMGB1 in gastric carcinoma tissues and normal tissues,including a total of 318 samples.Overall,HMGB1 expression in gastric carcinoma is higher than in normal tissue (P=0.002).Moreover,in Kaplan-Meier Plotter study,patients with low expression of HMGB1 have a better survival (P=1.8E-05).Conclusion HMGB1 mRNA was found highly expressed in gastric carcinoma tissue and the expression of HMGB1 mRNA has a significant impact on survival of intestinal-type gastric carcinoma,which provides the basis for exploring the role of HMGB1 in gastric cancer,and provides an important theoretical basis for future clinical treatment and prognostic studies of gastric cancer. |
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