汪孟然,闫中瑞,司翠平.远隔缺血适应对脑血管病的影响及分子机制[J].济宁医学院学报,2017,40(5):376-381 |
远隔缺血适应对脑血管病的影响及分子机制 |
Effects and molecular mechanism of remote ischemic conditioning in the cerebrovascular disease |
投稿时间:2017-08-09 |
DOI:10.3969/j.issn.1000-9760.2017.05.015 |
中文关键词: 远隔缺血适应;脑血管病;机制 |
英文关键词: Remote ischemic conditioning;Cerebrovascular disease;Mechanism |
基金项目:山东省自然科学基金项目(ZR2015HL039)。 |
作者 | 单位 | E-mail | 汪孟然 | 济南大学山东省医学科学院医学与生命科学学院, 济南 250022 济宁医学院附属济宁市第一人民医院, 济宁 272011 | | 闫中瑞 | 济宁医学院附属济宁市第一人民医院, 济宁 272011 | zhongruiy@163.com | 司翠平 | 济宁医学院附属济宁市第一人民医院, 济宁 272011 | |
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中文摘要: |
脑血管病严重威胁着人类健康,但目前尚无有效、易行的防治方法。远隔缺血适应(remote ischemic conditioning,RIC)是通过给予某一器官短暂的缺血刺激引发内源性保护反应,从而减轻另一器官缺血性损伤,是防治脑血管病的一种新方法。RIC在脑梗死、蛛网膜下腔出血、颅内动脉粥样硬化性狭窄以及血管性认知障碍患者的防治中起着积极作用,其机制主要是通过释放内源性保护物质,引起细胞内相关蛋白的改变,并介导细胞内新蛋白的合成及基因的调控完成的。本文对RIC在脑血管病防治中的应用及机制进行综述。 |
英文摘要: |
Cerebrovascular disease is a serious threat to human health,but there is no effective and feasible prevention measurements.Remote ischemic conditioning(RIC)is the phenomenon whereby transient organ ischemia evokes an endogenous response such that a different organ is protected against injurious ischemia.It is a new paradigm in the treatment of cerebrovascular disease.Researches have shown that RIC plays a neuroprotective role in cerebral infarction,subarachnoid hemorrhage,intracranial atherosclerotic stenosis and vascular cognitive impairment.The neuroprotective mechanism of RIC may be related to the change of related proteins and mediating new protein synthesis,gene regulation in cells by releasing endogenous protective substances and humoral factors.The effects and neuroprotective mechanisms of RIC on cerebrovascular disease were summarized. |
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