| 邵元霞.重组人脑利钠肽治疗重症心肌炎合并心力衰竭患者临床观察[J].济宁医学院学报,2016,39(6):399-401 |
| 重组人脑利钠肽治疗重症心肌炎合并心力衰竭患者临床观察 |
| Clinical study of recombinant human brain natriuretic peptide treating severe myocarditis with heart failure |
| 投稿时间：2016-10-09 |
| DOI：10.3969/j.issn.1000-9760.2016.06.005 |
| 中文关键词: 重组人脑利钠肽;重症心肌炎;心力衰竭;左室射血分数;Super-Score评分 |
| 英文关键词: Recombinant human brain natriuretic peptide;Severe myocarditis;Heart failure;LVEF;Super-Score |
| 基金项目: |
| 作者 | 单位 | | 邵元霞 | 济宁医学院附属济宁市第一人民医院, 济宁 272000 |
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| 中文摘要: |
| 目的 探讨重组人脑利钠肽（rhBNP）在重症心肌炎合并心力衰竭患者中应用的临床疗效。方法 选取2012年7月至2016年6月在我院住院治疗的急性心肌炎合并心力衰竭患者108例，随机分为观察组（50例）和对照组（58例）。两组均给予常规抗心力衰竭治疗，观察组在常规治疗的基础上静脉泵入rhBNP （先以负荷剂量1.5μg/kg静推，再予维持剂量0.0075μg/kg/min持续泵入）。治疗72h后观察两组患者用药前后血清N末端脑钠肽前体（NT-proBNP）水平、超声心动图评价左室射血分数（LVEF），并重新评估患者心功能（NYHA分级）及Super-Score评分。结果 治疗后两组NT-proBNP水平均下降，观察组更明显（P<0.05），两组LVEF值、心功能均提高，观察组更明显（P<0.05）。结论 rh-BNP治疗重症心肌炎合并心力衰竭患者疗效显著，可明显改善患者的心力衰竭症状。 |
| 英文摘要: |
| Objective To investigate the clinical effects of recombinant human brain natriuretic peptide (rh-BNP) in the treatment of severe myocarditis with heart failure.Methods A total of 108 patients with severe myocarditis heart failure at our hospital from July 2012 to June 2016 were randomly divided into rh-BNP treatment group (50 cases) and conventional treatment group (58 cases).Both groups were treated with conventional drugs against heart failure.Besides routine therapy,the rh-BNP group received rhBNP (1.5μg/kg bolus intravenous injection followed by 0.0075μg/kg/min continuous infusion).The plasma NT-prdBNP and LV EF value were evaluated by Ultrasonic echocardiography.NYHA heart function classification and SUPER SCORE of two groups were reappraised before and after treatment were observed.Results Compared with before treatment in 72 hours,both group were significantly lower in NT-proBNP and higher in LVEF value and heart function.Treatment group were more obvious than control group (P<0.05).Conclusion Rh-BNP,being capable of ameliorating heart failure symptoms of patients evidently,has significant therapeutic effects in the treatment of heart failure in patients with severe myocarditis. |
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